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With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors Volume 1 fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types - lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection.
List of contents
I. GENERAL APPLICATIONS
1. Brain Metastases - Albert S. Braverman
2. Epidemiology of Central Nervous System Metastases - Xiao-tang Kong, Daniela Alexandru, and Daniela A. Bota
3. Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases - Chiara Calatozzolo, Emilio Ciusani, Elena Corsini, Francesco Di Meco, Bianca Pollo, and Andrea Salmaggi
4. Non-Uniform Distribution of Metastatic Intracranial Tumors in Cancer Patients - Carlo C. Quattrocchi, Yuri Errante, Carlo Augusto Mallio, and Bruno Beomonte Zobel
5. Targeting Angiogenesis, Enhancing Radiosensitization and Crossing the Blood - Brain Barrier for Brain Metastases - Emmanouil Fokas
6. Second Malignancies in Children following Treatment for Neuroblastoma - Albert Garaventa, and Bruno De Bernardi
7. The Role of Chemotherapy in Metastatic Brain Tumors - Lynn Mubita and Steven N. Kalkanis
8. Multiple Metastases to Brain from Primary Cancers: Whole Brain Radiotherapy - Hany Soliman, Arjun Sahgal and Mary Tsao
9. Synoval Sarcoma Metastasized to the Brain - Nikolaos Sakellaridis and Lygeri Sakellaridi
II. BRAIN METASTASES FROM NON-SMALL CELL LUNG CARCINOMA
10. Multiple Small Brain Metastases with Limited Focal Brain Edema from Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Mutations - Akimasa Sekine
11. Brain Metastases of Patients with Lung Adenocarcinoma: Epidermal Growth Factor Receptor Mutations and Response to Whole-Brain Radiation Therapy - Shang-Gin Wu and Jin-Yuan Shih
12. Metastatic Spread of Lung Cancer to Brain and Liver: Role of CX3CR1 - David James Pinato and Francesco A. Mauri
13. Solitary Brain Metastasis from Non-Small Cell Lung Cancer: Treatment with Linac-Based Stereotactic Radiosurgery - Filippo Alongi, Umberto Ricardi, and Marta Scorsetti
14. Brain Metastases from Non-Small Cell Lung Cancer: Clinical Benefits of Erlotinib and Gefitinib - M. Houman Fekrazad, Omid Sanaei, Julie E. Bauman, and Dennie V. Jones, Jr.
15. Bispecific Targeted Toxin Dtategf against Metastatic NSCL Brain Tumors - Walter A. Hall, Jun Huang, Yan Michael Li and Daniel A. Vallera
16. Intracranial Disease in Patients with Non-Small Cell Lung Cancer: Treatment with Erlotinib - Mazhar Ajaz, Fiona McDonald, Jaishree Bhosle, Paola Bordi, and Mary O'Brien
17. Radiation Management of Synchronous Brain Metastases from Non-Small Cell Lung - Allison Ashworth, David Palma, and George Rodrigues
18. Brain Metastases after Prophylactic Cranial Irradiation in Patients with Small Cell Lung Cancer Responding to Chemotherapy - Tak Hing Patricia Tai, Avi Assouline, Kurian Joseph, Joseph Siu-kie Au, and Edward Yu
III. BRAIN METASTASES FROM SMALL CELL LUNG CARCINOMA
19. Brain Metastases from Small-Cell Lung Cancer with High Levels of Placental Growth Factor - Yu-Hua Chen and Bo Li
20. Brain Metastases from Lung Cancer - Amol J. Ghia and Ritsuko Komaki
21. Lambert-Eaton Myasthenic Syndrome and Brain Metastases from Occult Small Cell Lung Carcinoma: a Clinician's Perspective - Arunansu Talukdar, Nikhil Sonthalia, Sayantan Ray, and Supratip Kundu
About the author
Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.
