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This book describes the complex structures of heparins and heparan sulfates (heparinoids) and how they are generated by their biosynthetic pathways. The book also details the methodologies for studying these structures and their cellular metabolism. Heparin-Binding Proteins introduces the general nature of interactions between heparinoids and proteins, and presents the role for these structures in their interactions with the proteins of the hemostatic mechanisms, fibroblasts growth factors, superoxide dismutase, and lipoproteins.
List of contents
Preface. Conventions, Abbreviations, And Terminology. Heparin Vs. Heparan Sulfate. Structures of Heparinoids. Experimental Approaches for Determining Heparinoid Structures. Structural Modification of Heparinoids. The Cellular Metabolism of Heparan Sulfate. Interactions Between Heparinoids and Proteins. Antithrombin: The Prototype for Heparin-Binding Proteins. Heparin-Binding Proteins in Hemostasis. Fibroblast Growth Factors. Extracellular Superoxide Dismutase. Heparin-Binding Proteins in Lipoprotein Metabolism. Epilog. Appendix: Other Heparin-Binding Proteins. Subject Index.
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"...a remarkable achievement... I found reading this book to be highly rewarding... highly valuable as an introduction to various aspects of heparin/heparan sulfate chemistry and biology." --Ulf Lindahl, Unviersity of Uppsala, Sweden, in JOURNAL OF MEDICINAL CHEMISTRY (1999)
