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Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.
List of contents
1. Overview
Aftab Ansari and Guido Silvestri
2. Historical perspective
Preston Marx
3. SIV infections in the wild
Cristian Apetrei and Martine Peeters
4. Virology of SIVs
Frank Kirchhoff
5. SIV infection of chimpanzees
Jonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt
6. Pathology of acute & chronic infection
Francois Villinger and Sanjeev Gumber
7. Mucosal immunity
Jason Brenchley
8. Innate immunity
Steven E. Bosinger and R. Keith Reeves
9. Humoral immune responses
Cynthia Ann Derdeyn and Reinhard Kurth
10. Cellular immune responses
Amitinder Kaur
11. Chronic immune activation
Donald Sodora
12. Pattern of infected cells
Mirko Paiardini and Thomas Howerton Vanderford V
13. Viral transmission
Ivona Pandrea and Ann Chahroudi
14. Genetics of the host
Lutz Walter
15. The different modes of HIV/SIV control in monkeys and humans
Lisa Chakrabarti
16. Humans resembling natural hosts
Amalio Telenti and Paul McLaren
Epilogue: Implications for HIV infection
Aftab Ansari and Guido Silvestri
About the author
Aftab Ansari, Ph.D. Dr. Aftab A. Ansari, Professor, Department of Pathology and Laboratory Medicine, Room 2309 WMB, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USAPh.D., University of Arizona, Tucson, Arizona, 1970 M.S., University of California, Los Angeles, CA, 1967 M.S., University of Karachi, Karachi, Pakistan, 1963 B.S., University of Karachi, Karachi, Pakistan, 1961 1981-present Senior Consultant, Naval Medical Research and Development Command, Bethesda, Maryland1985-Present Professor, Department of Pathology and Laboratory Medicine, Emory University1999-present Scientific Advisor, U.S. Naval Medical Research Unit #2, Jakarta, Indonesia.2002-present Scientific Advisory Board, One World Health, San Francisco, CA.2001-2008 Scientific Advisory Board, Lipid Sciences, Inc. Pleasanton, CA.2005-present Scientific External Advisory Board member, CAHDR, Meharry Medical College, Nashville, TN2008-present Scientific Advisory Board, SMART Technologies, Inc., Rehovot, Israel2007-present Member, FDA Expert Panel, FDA Center for Devices and Radiological Health (CDRH), SGE, Deptt. Of Health & Human Services, Immunology Devices PanelProfessor Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USAChief, Division of Microbiology and Immunology, Yerkes National Primate Research Center Georgia Research Alliance Eminent Scholar in Comparative Pathology, Emory University
