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Low-Abundance Proteome Discovery addresses the most critical challenge in biomarker discovery and progress: the identification of low-abundance proteins. The book describes an original strategy developed by the authors that permits the detection of protein species typically found in very low abundance and that may yield valuable clues to future discoveries. Known as combinatorial peptide ligand libraries, these new methodologies are one of the hottest topics related to the study of proteomics and have applications in medical diagnostics, food quality, and plant analysis. The book is written for university and industry scientists starting proteomic studies of complex matrices (e.g., biological fluids, biopsies, recalcitrant plant tissues, foodstuff, and beverage analysis), researchers doing wet chemistry, and graduate-level students in the areas of analytical and biochemistry, biology, and genetics.
List of contents
Antiphon1. Introducing low-abundance species in proteome analysis2. Chromatographic and electrophoretic pre-fractionation tools in proteome analysis3. Current low-abundance protein access4. Low-abundance protein access by combinatorial peptide libraries5. Plant proteomics and food and beverage analysis via CPLL capture6. Biomedical involvements of low-abundance proteins7. Other applications of combinatorial peptide libraries8. Detailed methodologies and protocolsPolyphony
