Oxidative Stress - Eustress and Distress

Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections:

• A conceptual framework for studying oxidative stress.
• Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress).
• The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution.
• Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer.
Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science.




List of contents










I. Conceptual
1. Oxidative Eustress and Oxidative Distress: Introductory Remarks
2. Epistemological challenges of the Oxidative Stress Theory of Disease and the problem of biomarkers
3. Systems Biology and Network medicine: An Integrated Approach to Redox Biology and Pathobiology
4. The Reactive Species Interactome
II. Oxidative Eustress and Distress: Processes and Responses
5. Oxidative stress and the early co-evolution of life and biospheric oxygen
6. How imaging transforms our understanding of oxidative stress
7. In vivo applications of chemogenetics in redox (patho)biology
8. Quantification of H2O2 in cells: methods and significance
9. The Keap1-Nrf2 pathway: From Mechanism to Medical Applications
10. Ferroptosis: physiological and pathophysiological aspects
11. Aquaporins: gatekeepers in the borders of oxidative stress and redox signalling
12. Extracellular superoxide dismutase (SOD3): an antioxidant or prooxidant in the extracellular space?
13. Protein S-glutathionylation and the regulation of cellular functions
14. Dual stressor effects of lipid oxidation and antioxidants
15. Oxidized phospholipid signaling: distress to eustress
16. Redox regulation of protein kinase signaling
17. FoxO transcription factors in the control of redox homeostasis and fuel metabolism
18. Oxidatively generated DNA base modifications: relation to eustress and distress
19. Light-Initiated Oxidative Stress
20. Nutritional Protection against Photooxidative Stress in Human Skin and Eye
III. Exposome
21. Mechanisms integrating lifelong exposure and health
22. Nutrient Sensing, the Oxidative Stress Response, and Stem Cell Aging
23. How exercise induces oxidative eustress
24. Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants
25. Traffic-related environmental risk factors and their impact on oxidative stress and cardiovascular health
IV. Oxidative Stress in Health and Disease Processes
26. Mitochondrial ROS production during ischemia-reperfusion injury
27. Redox signaling in cellular differentiation
28. Redox regulated brain development
29. Eustress, Distress, and Oxidative Stress: Promising Pathways for Mind-Body Medicine
30. Reactive Oxygen Species and Cancer
31. Perspectives of TrxR1-based cancer therapies
32. Oxidative/nitrosative stress and hepatic encephalopathy
33. ROS Signaling in Complex Systems: The Gut
34. Oxidative stress in skeletal muscle: Unravelling the potential beneficial and deleterious roles of reactive oxygen species
35. Redox Mechanisms in Pulmonary Disease: Emphasis on Pulmonary Fibrosis
36. Dicarbonyl stress and the glyoxalase system
37. Redox distress in organ fibrosis: the role of non-coding RNAs




About the author

Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named ‘Redox Pioneer’; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of “Oxidative Stress” in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.

Product details

• Assisted by: Helmut Sies (Editor), Sies Helmut (Editor)
• Publisher: Elsevier
• Languages: English
• Product format: Paperback / Softback
• Released: 06.11.2019
• EAN: 9780128186060
• ISBN: 978-0-12-818606-0
• Dimensions: 191 mm x 235 mm x 45 mm
• Weight: 1720 g
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Molecular Biology, biochemistry, molecular biology, Enzymology