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Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born.
This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.
List of contents
1. Generational epigenetic inheritance
SECTION I Definitions and history of generational epigenetic inheritance
2. Definition of epigenetic transgenerational inheritance and biological impacts
3. Historical perspective of transgenerational epigenetics
SECTION II Germline epigenetics
4. Epigenetic changes in the mammalian paternal germ line
SECTION III Parental epigenetic inheritance
5. Maternal epigenetic inheritance
6. Paternal epigenetic inheritance
SECTION IV Basic mechanisms/processes of epigenetic inheritance
7. Towards the molecular mechanisms of transgenerational epigenetic inheritance: insights from transgenic mice
8. Histone-mediated transgenerational epigenetics
9. Heritable generational epigenetic effects through small noncoding RNA
10. Long noncoding RNA and epigenetic inheritance
SECTION V Model organisms
11. Nonmammalian model organisms in epigenetic research:an overview
12. Plant models of transgenerational epigenetic inheritance
13. Epigenetics and heritable phenotypic variations in livestock
14. Transgenerational epigenetic inheritance in insects
SECTION VI Evolution of transgenerational epigenetics
15. Evolutionary perspectives on transgenerational epigenetics
16. Inheritance of epigenome variants across generations during evolution
SECTION VII Environmental epigenetic effects on the offspring
17. Transgenerational epigenetics of endocrine-disrupting chemicals in mammals
18. Transgenerational effects of imprinting
19. Epigenetic inheritance across multiple generations
SECTION VIII Impact of transgenerational epigenetics on disease
20. Transgenerational epigenetics, paternal obesity, and insulin resistance
21. Epigenetic inheritance of type 2 diabetes
SECTION IX Clinical significance of transgenerational epigenetics
22. Clinical aspects of transgenerational epigenetics
About the author
Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
