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Rajesh Pandey's lab focuses on Integrative Genomics of Host-Pathogen wherein RNA plays a central role towards modulating pathogenicity. RNA-Based Regulation in Human Health and Disease offers an in-depth exploration of RNA-mediated genome regulation at different hierarchies. Beginning with a multitude of canonical and noncanonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts, and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational), and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic and neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students, and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. --
List of contents
1. Introduction
2. Non-coding RNAs: ever-expanding diversity of types and functions
3. Functional categories of RNA regulation
4. The dynamic aspects of RNA regulation
5. RNA beyond humans
6. Extracellular RNA in human health and disease
7. RNA and malaria pathogenesis
8. RNA and metabolic disorders
9. RNA toxicity in tandem nucleotide repeats mediated neurodegenerative disorders
10. Regulation by non-coding RNAs in respiratory disorders
11. RNA in cancer
12. RNA and inflammatory autoimmune diseases
13. RNA and bacterial infection
14. RNA and stress
15. RNA and aging
16. Experimental toolkit to study RNA level regulation
17. Industry perspective
18. Summary and future perspectives
About the author
In earning his PhD, Dr. Rajesh Pandey used a combination of functional genomics and computational tools to elucidate the role of noncoding RNA during stress response. This convinced him of the potential of the RNA regulatory repertoire and its role in shaping human evolution, health, disease states, diagnosis, prognosis, and therapeutics. Subsequently, he has employed diverse genomic toolkits to understand and explore RNA-level regulation at different hierarchies, encompassing human, mouse, plant, fungi, bacteria genomics, and metagenomics. In addition to his research work, Dr. Pandey has been a tutor at many workshops on applications of NGS technologies, and has published peer reviewed papers in such journals as Genome Biology; Genome Biology and Evolution; Nucleic Acids Research; Journal of Cell Science; PLOS Genetics; Frontiers in Microbiology; Scientific Reports; Molecular Cell; and Clinical Genetics. His future interest lies in investigating the role of noncoding RNA in modulating human phenotypic variation and its impact on health and disease spectrum.
