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Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome.
The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries.
List of contents
1. Historic accounts of neuron regeneration
2. Reagents for neuron regeneration structural studies
3. Assessments for functional regeneration
4. In vitro methods
5. In vivo models and pharmacological reagents
6. Systems biology approaches
7. Application of machine learning and artificial intelligence
8. Standardization approaches
9. Re-connectivity and new approaches
10. Regeneration applicable to other fields
11. Food and drug administration outlook for new treatments in this area
12. Approval processes and clinically relevant aspects
13. Enterprise formation strategies
14. Protocols and miscellaneous topics
About the author
Sanjoy Bhattacharya is a tenured full Professor at the Department of Ophthalmology, University of Miami, with secondary appointments in biochemistry, molecular biology, neuroscience, cellular and molecular pharmacology programs. He earned his doctorate in Biochemical Engineering and Biotechnology. Dr. Bhattacharya’s laboratory, with its diverse expertise in engineering, computer programming, biology, and mass spectrometry, is dedicated to studying the complete set of molecules and biological systems involved in axon regeneration. He serves on the editorial board of several peer-reviewed journals including PLoS One as an academic editor, Experimental Eye Research as Special issues and Review editor, and Translational Metabolomics as the Editor in Chief. Professor Bhattacharya has held several leadership positions including Chair of the scientific advisory board of Malignancy Research Foundation and Chair of Miller School of Medicine Faculty Council. He is also the founding director of Miami Integrative Metabolomics Research Center.
