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Biomechanics of the Aorta: Modeling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.
List of contents
PART 1 Anatomy, biology, physiopathology 1. Physiopathology 2. Genetics of aortic disease 3. Mechanobiology of aortic cells and extracellular matrix 4. Clinical treatment options
PART 2 Imaging and tissue/rheology characterization 5. Novel experimental methods to characterize the mechanical properties of the aorta 6. Imaging aortic flows in 4D using MRI 7. Ultrasound imaging for aortic biomechanics 8. Functional imaging, focus on [18F]FDG positron emission tomography 9. Image processing: Deep learning for aorta model reconstruction
PART 3 Tissue modeling and rupture 10. On simulation of the biophysical behavior of the aortic heart valve interstitial cell 11. Abdominal Aortic Aneurysm and thrombus modeling 12. Computational modeling of aneurysm growth in mechanobiology 13. Analysis of aortic rupture: A computational biomechanics perspective 14. Multiscale modeling of aortic mechanics: Tissue, network, and protein
PART 4 Flow modeling and algorithm 15. Multiphysics flow modeling in the aorta 16. Novel Approaches for the numerical solution of fluid-structure interaction in the Aorta 17. Turbulence modeling of blood flow 18. Inverse problems in aortic flow modeling 19. Modeling of flow induced mechanosignaling 20. Reduced order modeling of cardiovascular hemodynamics
PART 5 Applications 21. Transcatheter aortic valve implantation (TAVI) 22. Abdominal Aortic Aneurysm rupture prediction 23. (T)EVAR simulation 24. Fluid Structure Interaction (FSI) in aortic dissections 25. Pharmacological treatments, mouse models, and the aorta
