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The book "Bacterial Polysaccharides Steroidal Glycosides Antigens" by Geeta Karki is a comprehensive guide to the complex world of bacterial biochemistry, microbiology, and immunology. This book covers various aspects of bacterial polysaccharides, steroidal glycosides, and antigens, which are essential for understanding bacterial pathogenesis and immunity. The book begins by exploring the fundamental concepts of bacterial cell walls, lipopolysaccharides, and other critical components of the bacterial structure. It then delves into the immunogenicity of these components and the use of adjuvants in vaccines. Structural biology and serotyping, especially O-antigens, are also discussed in detail. The book also explores the pathogenesis of bacterial infections caused by Gram-negative bacteria and their capsules and lipoo ligosaccharides. The host-pathogen interactions and the immune response to these infections are explained in detail. The biosynthesis of bacterial polysaccharides, glycoconjugates, and carbohydrate-based vaccines is also covered in this book. The antigenic variation and bacterial virulence mechanisms that aid in immune evasion are also discussed. The book provides insight into the molecular biology of bacterial genetics and the evolution of bacteria. It also covers the use of glycomics, glycoengineering, and glycan arrays to develop glycosyltransferases, carbohydrate-protein conjugates, glycopeptides, and glycolipids for better understanding bacterial adhesion and mucosal immunity.
Overall, this book is an essential reference for researchers, students, and professionals in the fields of microbiology, immunology, and biochemistry. It provides a comprehensive overview of bacterial polysaccharides, steroidal glycosides, and antigens and their roles in bacterial pathogenesis and immunity
