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The extracellular domain of FNDC5 is proposed to be cleaved into a peptide hormone named 'irisin' after the Greek messenger goddess 'Iris'. Irisin has been shown to play an important role in various physiological conditions. Irisin has been shown to be in increased levels in muscle tissue after exercise in some studies, whereas, others showed no effect of exercise on irisin levels. Several studies shown that, irisin reduce insulin resistance, adiposity and the effects of other adiposity-based pathological conditions. In this book, we presented whether the commercial antibodies generated against various regions of the irisin/FNDC5 are capable of identify the full-length and truncated forms of irisin and reported the biological effects of recombinant irisin, which were expressed in E. coli.
About the author
Dr. Kalpana Panati is Assistant Professor in Biotechnology at Govt. College for Men, Kadapa, A.P, India. Her research interests are focused on the recombinant DNA, oxidative stress and inflammation. Dr. Y. Suneetha is working as Assoc. Professor in S.V. University, Tirupati and Dr. Narala VR is working as Assoc. Professor in Yogi Vemana University.
