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Informationen zum Autor Professor Robert R. Crichton, Unité de Biochimie, Belgium. Professor Roberta J. Ward, Unité de Biochimie, Belgium. Klappentext As life expectancy increases in the developed world, so does the incidence of neurodegenerative diseases of the human brain. Metal-Based Neurodegeneration provides a molecular biology perspective of many of the neurodegenerative diseases which currently plague humankind, including: Alzheimer's Disease Parkinson's Disease Creutzfeldt-Jakob disease Familial amyotrophic lateral sclerosis Friedreich's ataxia Multiple sclerosis Wilson's disease Hallervorden-Spatz syndrome Huntington's disease In a dedicated chapter for each disease the characteristics of the disease are described along with the biochemical actors, including their normal, and pathological conformations. Emphasis is given on the role of metal-induced oxidative stress in the disease process, often resulting in the production of intracellular aggregates of the target proteins or peptides, including b-amyloid plaques and neurofibrillary tangles in Alzheimer's disease, Lewy bodies in Parkinson's disease, prion protein (PrP) plaques in prion diseases and nuclear inclusions in Huntington's. Finally the authors discuss the progress that is being made in understanding the pathogenesis of the diseases and the identification of targets for their treatment. Metal-Based Neurodegeneration is an essential survey of the molecular origin of neurodegenerative diseases for clinical and research scientists working in gerontology, neuropathology, metalloprotein mechanisms, and anyone with an interest in the diseases of ageing. Zusammenfassung This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson's disease! CJD and Huntington's disease! and gives indications of the prospects for therapy! based on the understanding of molecular defects involved in these diseases. Inhaltsverzeichnis Preface. 1 Metals in Brain, Metal Transport, Storage and Homeostasis. 1.1 Introduction - the importance of metal ions in brain function. 1.2 Metal ion transport and storage - iron. 1.3 Metal ion transport and storage - copper. 1.4 Metal ion transport and storage - zinc. 1.5 Metal ion transport and storage - other metals. 1.6 Metals and their homeostasis (with particular reference to iron and copper). References. 2 Oxidative Stress and Redox-Active Metal Ions. 2.1 Introduction - the oxygen paradox. 2.2 Reactive oxygen species (ROS). 2.3 Reactive nitrogen species (RNS). 2.4 The targets of ROS and RNS. 2.5 Cytoprotection against oxidative damage. 2.6 Mitochondria, free radicals and signalling. 2.7 Cyclin-dependent kinases. 2.8 Apoptosis - programmed cell death. 2.9 ROS, RNS and signal transduction. 2.10 Molecules involved in the inflammatory pathway. References. 3 Parkinson's Disease. 3.1 Proteins involved in Parkinson's disease. 3.2 Metal involvement in Parkinson's disease. 3.3 Risk factors for Parkinson's disease. 3.4 Mitochondrial dysfunction. 3.5 Role of dopamine in Parkinson's disease. References. 4 Alzheimer's Disease. 4.1 Proteins involved in Alzheimer's disease. 4.2 Metal involvement in Alzheimer's disease. 4.3 Genetic and risk factors. 4.4 Mitochondrial function in Alzheimer's disease. 4.5 Oxidative stress. 4.6 Role of acetyl choline in Alzheimer's disease. References. 5 Huntington 's Disease and Polyglutamine Expansion Neurodegenerative Diseases. 5.1 Introduction - an overview of trinucleotide expansion diseases. 5.2 PolyQ diseases. 5.3 Structural models of polyQ protein aggregation. 5.4 Mechanisms of cell ...
