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The variety of chemically diverse pharmacological agents administered to patients is large and continues to expand and with every new drug released, there is always potential for adverse reactions, some of them allergic . With its roots in immunology and pharmacology, the science of drug allergy is becoming better understood and applied as its importance is increasingly recognized throughout the many branches of medicine. Drug Allergy: Clinical Aspects, Diagnosis, Mechanisms, Structure-Activity Relationships sheds new light on this field. C omprehensive in design, this authoritative title identifies the most important culprit drugs implicated in immediate and delayed drug hypersensitivities and offers up-to-date information on classifications, diagnoses, underlying mechanisms and structure-activity relationships. Chapters dealing with the molecular and cellular mechanisms of drug hypersensitivities, non-immune-mediated sensitivities and diagnostic methods are presented as introductory material for in-depth treatises on the beta-lactam antibiotics, other antibiotics and antimicrobials, drugs used in anesthesia and surgery, opioid analgesics, corticosteroids, monoclonal antibodies and other biologics, drugs used in chemotherapy, proton pump inhibitors, iodinated and gadolinium-based contrast media and non-steroidal anti-inflammatory drugs. In addition to being of immense value to clinicians, other health care professionals and researchers, this title will prove invaluable for those taking undergraduate and graduate courses in science and will also serve as a useful text for students of medicine, pharmacy, nursing and dentistry.
List of contents
Preface
Chapter 1 Adverse Reactions to Drugs and Drug Allergy: Scope of this Book
Chapter 2 Classification and Descriptions of Allergic Reactions to Drugs
Chapter 3 Mechanisms of Hypersensitivity
Chapter 4 Diagnosis of Allergic Reactions to Drugs
Chapter 5 beta-Lactam Antibiotics
Chapter 6 Other Antimicrobial Drugs
Chapter 7 Drugs and Other Agents Used in Anesthesia and Surgery
Chapter 8 Opioid Analgesic Drugs
Chapter 9 Non-Steroidal Anti-Inflammatory Drugs
Chapter 10 Contrast Media
Chapter 11 Biologics
Chapter 12 Corticosteroids
Chapter 13 Drugs Used for Chemotherapy
Chapter 14 Proton Pump Inhibitors
Postface
Report
From the reviews:
"The current book offers valuable knowledge regarding mechanisms, clinical aspects, diagnostic methods, and therapeutic approach in drug allergy, which will aid the caring physician to successfully diagnose and manage affected individuals. ... The summary points at the end of each chapter represent an outstanding feature of this book. As a comprehensive overview of the mechanisms, clinical manifestations and diagnostic methods in drug allergy will provide valuable and practical information for every physician interested in this disease." (Juan Carlos Aldave, World Allergy Organization, worldallergy.org, February, 2014)
"Book presents the science behind what truly is an allergic reaction to guide evidence-based decisions on drug therapy. It addresses the clinical aspects of allergy in addition to the mechanism of disease, the molecular chemistry behind allergy, and other key features. ... Although this can be a valuable reference for anyone in healthcare, the primary audience is composed of physicians, pharmacists, and nurses, as well as students ... . a great reference for those who wish more information or are preparing lectures on this topic." (Patrick J. McDonnell, Doody's Book Reviews, October, 2013)
