G Protein-Coupled Receptors in Drug Discovery

Informationen zum Autor Kenneth H. Lundstrom! Mark L. Chiu Klappentext With more than half of drug targets based on GPCRs! translating into billions in worldwide sales! there is great interest in finding high-resolution structures for recombinantly expressed GPCRs! discovering novel drug interactions! and designing tailor-made! structure-based drug therapies that display improved efficacy and selectivity with lesser side effects. This book describes the physiological role of GPCRs and their involvement in various human diseases. Chapters present current approaches in drug discovery that include target selection! establishment of screening! functional assays for GPCRs! and the continuous de-orphanization process of orphan GPCRs. The book also covers recombinant GPCR expression for drug screening and structural biology! different methods to obtain structural information on GPCRs! and the importance of bioinformatics. Zusammenfassung The range of G protein-coupled receptors have an enormous impact on the process of drug development. This work describes the physiological roles of GPCRs and their involvement in various human diseases. It presents approaches in drug discovery that include target selection, establishment of screening and functional assays. Inhaltsverzeichnis Introduction. G Protein-Coupled Receptors as Targets for Drug Discovery. G Protein-Coupled Receptors in Cardiovascular Diseases. G Protein-Coupled Receptors in Cancer. G Protein-Coupled Receptors in Metabolic Disease. G Protein- Coupled Receptors in CNS Drug Discovery. Recombinant G Protein-Coupled Receptors for Drug Discovery. High Throughput Screening Assays for G Protein-Coupled Receptors. Bioinformatics/ Molecular Modelling of G Protein-Coupled Receptors. Structure and Dynamics of G Protein-Coupled Receptors. Toward Crystallization of G Protein-Coupled Receptors. Novel Solid-State NMR Methods for Structural Studies on G Protein-Coupled Receptors. Structural Genomics Initiatives on G Protein-Coupled Receptors. Dimerization of G Protein-Coupled Receptors. Orphan G Protein-Coupled Receptors. ...

Product details

• Authors: Mark Chiu, Kenneth G Lundstrom, Kenneth G. Lundstrom, Kenneth H. (Flamel Technologies Lundstrom, Kenneth H. Chiu Lundstrom, Lundstrom H. Lundstrom, LUNDSTROM KENNETH G
• Assisted by: Mark L. Chiu (Editor), Mark L. (Abbott Laboratories Chiu (Editor), Chiu Mark L. (Editor), Kenneth H. Lundstrom (Editor), Kenneth H. (Flamel Technologies Lundstrom (Editor), Lundstrom Kenneth H. (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 11.07.2005
• EAN: 9780824725730
• ISBN: 978-0-8247-2573-0
• No. of pages: 376
• Series: Drug Discovery Series; Drug Discovery Series
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Medical research, MEDICAL / Pharmacy, SCIENCE / Chemistry / General, MEDICAL / Pharmacology, Biology, life sciences, Pharmacology, Pharmaceutical technology, Pharmaceutical chemistry and technology