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Informationen zum Autor Eric Newsholme , Merton College and Department of Biochemistry, University of Oxford, UK. Tony Leech , Gresham's School, Norfolk, UK. Klappentext Functional Biochemistry in Health and Disease provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice. Carefully structured within five sections, each biochemical, physiological or medical subject that is covered in the book is presented in one complete chapter. Consequently, each subject can be read and studied in isolation although cross-sectional links between the subjects are included where necessary. Background material, both biochemical and medical, that is necessary for an understanding of the subject, is included at the start of each chapter and clear, relevant diagrams enhance students' understanding. * Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective. * Clear presentation that minimises the use of jargon. * Each chapter contains boxes on related topics, relevant diagrams and a brief glossary. * Coverage includes athletic performance, apoptosis and the immune system. * Key historical developments are included to show how modern biochemistry has evolved. By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry. Zusammenfassung Dieses Grundlagenwerk nähert sich seinem Stoff über die übergeordneten Fragestellungen. So werden biochemische Reaktionen und Stoffwechselvorgänge nicht anhand einzelner Moleküle, sondern hinsichtlich der physiologischen Zusammenhänge und ihrer klinischen Bedeutung erklärt. Inhaltsverzeichnis Abbreviations. I INTRODUCTION. 1 The Structural and Biochemical Hierarchy of a Cell and a Human. Cell structure. Tissues. The whole human. The biochemical hierarchy. II ESSENTIAL TOPICS IN DYNAMIC BIOCHEMISTRY. 2 Energy: In the Body, Tissues and Biochemical Processes. Energy transformations in the whole body. Energy transformations in tissues and organs. Energy transformation in biochemical reactions and pathways. Adenosine triphosphate: its role in the cell. 3 Enzymes: Activities, Properties, Regulation and Physiology. Nomenclature and classifi cation. Basic facts. Mechanisms by which an enzyme enhances the rate of a reaction. Cofactors and prosthetic groups. Factors that change the activity of an enzyme. Allosteric inhibition. The physiological signifi cance of Km and Vmax values. Enzymes as tools. Enzymes in diagnosis. Enzymes as therapeutic agents. Enzymes as targets for therapy. Kinetic structure of a biochemical pathway. Regulation of enzyme activity. 4 Transport into the Body: The Gastrointestinal Tract, Digestion and Absorption. Gross structure of the gastrointestinal tract. Biochemistry of cooking and food preparation. Digestion and absorption. The gastrointestinal tract and disease. 5 Transport into the Cell: Particles, Molecules and Ions. Structure of the plasma membrane. Diffusion through membranes. Active transport. Endocytosis and exocytosis. Physiological...
