ORGANIC SYNTHESIS - DISCONNECTION APPROACH

Informationen zum Autor Dr Stuart Warren, Department of Chemistry, University of Cambridge, UK Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley), Organic Synthesis: Strategy and Control (Wiley) and Organic Chemistry (OUP). Dr Paul Wyatt, School of Chemistry, University of Bristol, UK Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. He is co-author, with Warren, of Organic Synthesis: Strategy and Control . Klappentext Organic Synthesis: The Disconnection Approach is the long-awaited second edition of a classic textbook; the first to provide a structured course in retrosynthesis- now an important technique used by generations of organic chemists. Now fully revised and updated with a modern look, 25 years of advances in organic synthesis are reflected with the addition of new examples and synthetic pathways. Additional material has been added to take the student to the level required by the bestselling sequel, "Organic Synthesis: Strategy and Control" and the later chapters have extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Zusammenfassung Organic Synthesis: The Disconnection Approach is the long-awaited second edition of a classic textbook; the first to provide a structured course in retrosynthesis- now an important technique used by generations of organic chemists. Now fully revised and updated with a modern look, 25 years of advances in organic synthesis are reflected with the addition of new examples and synthetic pathways. Additional material has been added to take the student to the level required by the bestselling sequel, "Organic Synthesis: Strategy and Control" and the later chapters have extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Inhaltsverzeichnis Preface ix General References xi 1. The Disconnection Approach 1 2. Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds 7 3. Strategy I: The Order of Events 17 4. One-Group C-X Disconnections 23 5. Strategy II: Chemoselectivity 29 6. Two-Group C-X Disconnections 35 7. Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy 45 8. Amine Synthesis 53 9. Strategy IV: Protecting Groups 61 10. One Group C-C Disconnections I: Alcohols 69 11. General Strategy A: Choosing a Disconnection 77 12. Strategy V: Stereoselectivity A 83 13. One Group C-C Disconnections II: Carbonyl Compounds 93 14. Strategy VI: Regioselectivity 101 15. Alkene Synthesis 107 16. Strategy VII: Use of Acetylenes (Alkynes) 115 17. Two-Group C-C Disconnections I: Diels-Alder Reactions 121 18. Strategy VIII: Introduction to Carbonyl Condensations 129 19. Two-Group C-C Disconnections II: 1,3-Difunctionalised Compounds 133 20. Strategy IX: Control in Carbonyl Condensations 139 21. Two-Group C-C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation 151 22. Strategy X: Aliphatic Nitro Compounds in Synthesis 161 23. Two-Group Disconnections IV: 1,2-Difunctionalised Compounds 167 24. Strategy XI: Radical Reactions in Synthesis 177 25. Two-Group Disconnections V: 1,4-Difunctionalised Compounds 185 26. Strategy XII: Reconnection 193 27. Two-Group C-C Disconnections VI: 1,6-diCarbonyl Compounds 199 28. General Strategy B: Strategy of Carbonyl Disconnections 207 29. Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles 217 30. Three-Membered Rings 229 31. Strategy XIV: Rearrangements in S...

Product details

• Authors: Stuart Warren, Stuart (Cambridge University Warren, WARREN STUART WYATT PAUL, Paul Wyatt, Paul (School of Chemistry Wyatt
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 21.11.2008
• EAN: 9780470712375
• ISBN: 978-0-470-71237-5
• No. of pages: 342
• Subject: Natural sciences, medicine, IT, technology