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Informationen zum Autor Stephen P. Arneric and Jorge D. Brioni are the authors of Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities, published by Wiley. Klappentext Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities Edited by Stephen P. Arneric and Jorge D. Brioni Nicotine's efficacy in the treatment of pain and anxiolysis, and its usefulness as a memory enhancer, have been suspected for many years, but research into the molecular biology of nicotinic acetylcholine receptors (nAChRs) traditionally has focused on smoking cessation. Now, thanks to recent technological advances in the molecular biology and electrophysiology of nAChRs, an abundance of evidence has emerged in support of nAChR ligands in the treatment of a range of CNS disorders, including Alzheimer's disease, Parkinson's disease, neuropathic pain, attention deficit disorder, and depression. Featuring contributions from an international team of experts in the field, this volume provides researchers and clinicians with a comprehensive review of nAChRs, their molecular biology, pharmacology, and clinical implications. Moving from the molecular to the clinical levels, the authors explore the latest developments in all areas of nAChR research, including: Molecular biology and biochemistry of nAChRs The physiological roles of nAChRs Pharmacokinetics of nicotine-like alkaloids Recent breakthroughs and emerging trends in nAChR medicinal chemistry Current and emerging therapeutic applications of novel nAChR ligands. A timely, authoritative review of basic research into nAChRs and their role in the development of new therapeutic strategies in the treatment of a range of various CNS diseases, Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities is required reading for neuroscientists, pharmacologists, medicinal chemists, biological psychiatrists, and psychopharmacologists. Zusammenfassung This text ties together basic research to the discovery of modern agents! and provides therapeutic strategies for the treatment of certain disorders of the central nervous system. It includes a comprehensive review of nicotinic receptors! from the molecular level to clinical applications. Inhaltsverzeichnis MOLECULAR BIOLOGY AND BIOCHEMISTRY. Purification and Cloning of Nicotinic Acetylcholine Receptors (J.Lindstrom). Transcriptional Regulation of Neuronal Nicotinic Receptor SubunitGenes (D. Fornasari, et al.). Molecular Composition and Biophysical Characteristics of NicotinicReceptors (J. Ramirez-Latorre, et al.). Desensitization and the Regulation of Neuronal Nicotinic Receptors(M. Marks). Cell Lines as Models for Studies of Nicotinic AcetylcholineReceptors (R. Lukas). Stable Expression of Human Neuronal Nicotinic Receptors (B.Buisson, et al.). PHYSIOLOGICAL ROLES OF NICOTINIC RECEPTORS. Functional Anatomy of Nicotinic Acetylcholine Receptors inMammalian Brain (P. Clarke). Nicotinic Receptor Modulation of Neurotransmitter Release (S.Kaiser & S. Wonnacott). Functional Diversity of Nicotinic Acetylcholine Receptors in theMammalian Central Nervous System: Physiological Relevance (E.Pereira, et al.). Diverse Functions of Neuronal Nicotinic Receptors Determined bySubcellular Location (D. Berg, et al.). Immunosuppressive and Anti-inflammatory Properties of Nicotine (M.Sopori). PHARMACOKINETICS OF NICOTINE-LIKE ALKALOIDS. Pharmacokinetics and Metabolism of Nicotine and Related Alkaloids(N. Benowitz & P. Jacob). Nicotine and Related Compounds as PET and SPECT Ligands (V.Villemagne, et al). MEDICINAL CHEMISTRY. Natural Products as a Source of Nicotinic Acetylcholine ReceptorModulators and Leads for Drug Discovery (M. Holladay, etal.). Nicotinic Cholinergic Receptor Pharmacophores (R. Glennon & M...
