The Oxford Handbook of Opioids and Opioid Use Disorder

The Oxford Handbook of Opioids and Opioid Use Disorder synthesizes research across the spectrum and establishes a foundational knowledge regarding historical and current epidemiological trends, neurobiological and genetic contributors to opioid effects and opioid use disorder (OUD), and core elements of opioid use such as withdrawal and craving. It also provides specific information and guidance regarding opioid treatment paradigms. This handbook will serve as a comprehensive guide for practitioners, policymakers, students, and researchers who wish to achieve a better understanding of the complex world of opioid and OUD practice and science.

List of contents

• Chapter 1: Historical Events that Shaped Contemporary Opioid Trends


• Kelly E. Dunn


• Chapter 2: Epidemiology of Opioid Use and Smoking, Alcohol, and Polysubstance Use Among Persons Using Opioids


• Maria A. Parker and Whitney S. Cordoba-Grueso


• Chapter 3 Opioid Use Disorder: Diagnostic History and Current Understanding


• Orrin D. Ware and Kelly E. Dunn


• Chapter 4: Access to Treatment for Opioid Use Disorder


• Brendan Saloner and Jason Gibbons


• Chapter 5: The Current Status of Medical Student Education on Opioids


• Oluwole Jegede, Peter J. Na, Ismene Petrakis, and Srinivas B. Muvvala


• Chapter 6: The Neurobiology of Opioid Use


• Shailesh N. Khatri, Erin E. Maher, Emma O. Bondy, and Cassandra D. Gipson


• Chapter 7: Genetic Influences in Opioid Use Disorder


• Jill Rabinowitz and Brion Maher


• Chapter 8: The Opioid Withdrawal Syndrome: Presentation, Measurement, and Management


• Kelly E. Dunn, Cecilia Bergeria, Orrin D. Ware, Eric C. Strain


• Chapter 9: Neonatal Abstinence Syndrome


• Sarah H. Heil, Heidi S. Melbostad, and Leigh-Anne Cioffredi


• Chapter 10: Opioid Craving: Understanding Its Measurement, Mechanisms, and Treatment


• Cecilia Bergeria and Brandon Park


• Chapter 11: Opioids and Cognition


• Bethea A. Kleykamp, Shannon B. Clarke, and Shauna P. Acquavita


• Chapter 12: Opioid Effects on Sleep: Review of the Literature and Consideration of the Hypothalamic-Pituitary-Adrenal Axis as a Relevant Mechanism


• Jennifer D. Ellis, Chung Jung Mun, and Patrick H. Finan


• Chapter 13: Fentanyl


• Kelly E. Dunn, H. Elizabeth Bird, and Caitlyn J. Durgin


• Chapter 14: Tramadol


• Kelly E. Dunn, Judy Ashworth, and Eric C. Strain


• Chapter 15: Kratom (Mitragyna speciosa): Pharmacology and Use of a Naturally Occurring Atypical Opioid


• Kirsten E. Smith, Oliver Grundmann, Marc T. Swogger, and Albert Garcia-Romeu


• Chapter 16: Ibogaine and Noribogaine


• Deborah C. Mash and Michael Karukin


• Chapter 17: Abuse Deterrent and Sustained Release Opioid Formulations


• Rachel R. Luba, Sandra D. Comer, and Edward V. Nunes


• Chapter 18: Methadone


• Jonathan R. Buchholz, Molly Kalmoe, Justin Stamschror, and Andrew J. Saxon


• Chapter 19: Buprenorphine


• Eric C. Strain and Andrew Gaddis


• Chapter 20: Naltrexone


• Marina Tsoy-Podosenin and Evgeny Krupitsky


• Chapter 21: Clonidine


• Mark S. Gold and Kenneth Blum


• Chapter 22: Lofexidine


• Charles W. Gorodetzky, Kristen L. Gullo, and Marc Fishman


• Chapter 23: Injectable Opioid Treatment


• Eugenia Oviedo-Joekes


• Chapter 24: Long-Term Treatment of Opioid Use Disorder With Medications


• Aaron S. Wolfgang, Melissa B. Weimer, Peter J. Na, David A. Fiellin, and Srinivas B. Muvvala


• Chapter 25: Supervised Withdrawal Opioid Use Disorder Treatments


• Kelly E. Dunn and Andrew S. Huhn


• Chapter 26: Psychosocial Treatment Methods


• Jessica M. Peirce, Denis G. Antoine, Alexis S. Hammond, and Michael S. Kidorf


• Chapter 27: Behavioral and Self-directed Treatments for Opioid Use Disorder


• Wendy Insalaco and J. Gregory Hobelmann


• Chapter 28: Contingency Management Treatment of Opioid Use Disorder


• August F. Holtyn, Forrest Toegel, and Matthew D. Novak


• Chapter 29: Treating Opioid Use During Pregnancy and Postpartum Life Phases


• Hendrée E. Jones


• Chapter 30: Pharmacy-Based Treatment Options for Opioid Use Disorder


• Ali Cheetham and Suzanne Nielsen


• Chapter 31: Opioid Overdose: Mechanisms and Naloxone


• Jermaine D. Jones, Rachel R. Luba, Mudassir Mumtaz, and Felipe Castillo


• Chapter 32: Opioid Overdose: Intervention Strategies


• Laura Brandt


• Chapter 33: Supervised Consumption Services


• Jeanette Bowles, Meaghan Thumath, Gillian Kolla, Zoe Dodd, Jaime Arredondo Sanchez Lira, Frank Crichlow, and Leo Beletsky


• Chapter 34: Psychiatric Comorbidities Among Persons Who Are Using Opioids


• R. Kathryn McHugh


• Chapter 35: Sex as a Biological Variable and Gender as a Social Construct in the Treatment of Opioid Use Disorder


• Andrew S. Huhn


• Chapter 36: Challenges of Opioid Use Disorder in Rural Settings


• Stacey C. Sigmon and Jennifer R. Havens


• Chapter 37: Differences Between Those Engaged in Heroin Use and Non-Prescribed Opioid Use


• Ty S. Schepis, Bowie Duncan, and Katherine Vrotsos


• Chapter 38: The Impact of Opioid Use Disorder on Families and Children


• Erin L. Winstanley, Amanda Newhouse, and Kari-Beth Law

About the author

Kelly E. Dunn, PhD, MBA, is Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University. Dunn has been working in the field of opioid use disorder since 2005, motivated by witnessing her community be ravaged with nonmedical use of prescription opioids as a teenager. This led to a passion for understanding motivations for opioid use, identifying methods to prevent the onset of opioid use disorder, improving treatments for opioid use disorder, and exploring new methods for managing pain and reducing opioid reliance. She has built a robust portfolio of laboratory and clinical trial research investigating these questions and is an author of more than 100 peer-reviewed publications in the area of substance use and opioid use disorder.

Summary

Opioids have played a prominent role in society for centuries and have been lauded for both their analgesic and euphoric qualities by cultures throughout the world. The advent of medical and pharmaceutical sciences in the 20th century ushered in a wide variety of different commercial opioid products that were designed to maximize their therapeutic potential. As the use of opioids increased, a corresponding need emerged to understand more about how opioids exert their effects in the body and brain; the consequences of opioid use regarding physical dependence, withdrawal, and craving; how we might best treat opioid use disorder (OUD) and address risk for opioid-related overdose; and how opioids may intersect with other clinical conditions to produce unique challenges.

Edited by Kelly E. Dunn, The Oxford Handbook of Opioids and Opioid Use Disorder synthesizes research across the spectrum, and establishes a foundational knowledge regarding historical and current epidemiological trends, neurobiological and genetic contributors to opioid effects and OUD, and core elements of opioid use such as withdrawal and craving. It provides specific information and guidance regarding opioid treatment paradigms, including chapters on specific pharmacotherapies as well as treatment approaches, and discusses considerations for special clinical populations. An overview of these respective issues is provided across 38 chapters, which outline the history and science of these topics alongside clinical considerations and case examples.

Written by expert bench scientists, epidemiologists, clinical trial interventionists, medical practitioners, and harm reduction specialists, this handbook will serve as a comprehensive guide for practitioners, policymakers, students, and researchers who wish to achieve a better understanding of the complex world of opioid and OUD practice and science.

Product details

• Authors: Dunn, Kelly E. (EDT) Dunn
• Assisted by: Kelly E Dunn (Editor), Kelly E. Dunn (Editor)
• Publisher: Oxford University Press
• Languages: English
• Product format: Hardback
• Released: 21.06.2024
• EAN: 9780197618431
• ISBN: 978-0-19-761843-1
• No. of pages: 1112
• Series: Oxford Library of Psychology
• Subjects: Humanities, art, music > Education > Kindergarten and pre-school education; PSYCHOLOGY / Clinical Psychology, PSYCHOLOGY / Psychopathology / Addiction, Addiction & therapy, Clinical psychology, Health psychology, Addiction and therapy