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Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding.
Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran.
List of contents
1. Peptide and Protein in Therapeutics
2. Hairy root culture: a reliable bioreactor from transgenic plants
3. Strategies for the ameliorated production of pharmaceutically important glycosides via plant cell culture
4. Peptide and protein delivery through cellulose, hyaluronic acid and Heparin
5. Peptide and protein delivery through Carageenan, Alginic acid, Agar and Myrrh
6. Peptide and protein delivery through acacia, tragacanth, and ghatti gum
7. Peptide and protein delivery through Chitin, chitosan and Starch
8. Peptide and protein delivery through Glycogen and Dextran
9. Peptide and protein in vaccine delivery
10. Analytical methods in detection of proteins and peptides in tissue fluids and homogenates
11. Factors affecting Peptide and protein absorption, metabolism and excretion
About the author
Dr. Aakanchha Jain is an Assistant Professor at the National Institute of Pharmaceutical Education and Research (NIPER) in Gandhinagar, Gujarat, India. Her research focuses on anticancer drug delivery, the role of caspase in cancer treatment, colon targeting, development of novel delivery systems of proteins and drugs for different diseases, and tropical and transdermal drug delivery. Dr. Jain has served as an editorial board member for EC Gastroenterology and Digestive System, and a guest reviewer for Carbohydrate Polymers, Pharmaceutical Development and Technology, and ACS Omega. She has received various awards and recognition for research, and has published widely in such peer reviewed journals as the Journal of Microencapsulation, Pharmaceutical Biotechnology, Journal of Biomaterial and Tissue Engineering, Journal of Pharmacognosy and Phytochemistry, Journal of Molecular Liquids, Drug Delivery and Translational Research, Journal of Controlled Release, and the Journal of Pharmaceutical Sciences and Pharmacology.Dr. Sonia Malik is a senior researcher at LBLGC, University of Orleans, France. After holding various research positions at Brazil, Czech Republic and Australia, she joined University of Orleans, France, as a Senior Researcher. Her research work is focused on enhanced and sustainable production of bioactive compounds from plants using different biotechnological approaches. She publishes regularly in peer-reviewed journals, and has served as a journals special issue and book editor on topics related to her area of expertise. She is the editorial board member and reviewer of many International scientific journals including Protoplasma, The Journal of Horticultural Science and Biotechnology, New Forests. She has visited many world leading cross-disciplinary research and teaching Institutions as a visiting researcher.
