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Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells.
In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry.
List of contents
1. Glycosidic Bond Formation Methodology: Challenges and Impact in Oligosaccharide Synthesis
2. Intramolecular Glycosylation: Opportunities and Challenges
3. Thioglycoside-Based Glycosylations in Oligosaccharide Synthesis
4. General Strategy for the Synthesis of N Glycosides
5. The Emerging Polyhydroxyazepanes Based C-Glycosides for Glycosidase Inhibition
6. Sialic Acid Donors: Stereoselective Chemical and Enzymatic O-Glycosylations
7. Synthetic Chemistry of D-Fructose
8. Recent Synthetic Strategies to Access Diverse Iminosugars
9. Vinyl Sugars in Diversity Oriented Synthesis
10. Synthesis of carbohydrate containing macrocycles
11. Recent Advances in Synthesis of Diverse Glycopeptides and Glycohybrids
12. Recent Advances on Carbohydrate-based Organocatalyst in Asymmetric Synthesis
13. Emerging Aspects of Domino Reaction in Carbohydrate Chemistry
About the author
Dr. Vinod K. Tiwari is Professor of Organic Chemistry at Banaras Hindu University. His teaching interest covers almost all branches of organic chemistry, and his research interest is highly focused on ‘Synthetic Carbohydrate Chemistry’. With more than 21 years of research and 17 years of teaching experience, Dr. Tiwari has supervised twelve PhD theses, twenty MS dissertations and contributed significantly to 150 peer-reviewed publications, several patents and invited book chapters of high repute. Dr. Tiwari's research has received many prestigious awards. He is an editorial board member of Trends Carbohydrate Res, Current Organic Chemistry, ARKIVOC, and J. Chem., and holds the Secretary position at the Association of Carbohydrate Chemist & Technologists, India. Recently, Dr. Tiwari edited a book Carbohydrates in Drug Discovery and Development for Elsevier.
