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Zusatztext "The authors have been quite successful in their efforts to provide a guide to scientists involved in the field of drug discovery with little-or-no knowledge of combinatorial chemistry?this overall instruction guide is a valuable companion to scientists involved in combinatorial work. ?The authors have succeeded in their endeavor by appraising several production methods! and comparing the costs for generating an entity through various research and development techniques." -Yesh P. Sachdeva! Synthesis! 2006 Informationen zum Autor Stanislav Miertus, Giorgio Fassina Klappentext Combinatorial Chemistry and Technology: Principles! Methods! and Applications! Second Edition provides comprehensive coverage of current combinatorial methodologies and technologies used in the design! synthesis! and screening of molecular libraries. It details the evolution of solid-phase chemistry! in vitro screening of biological activities and explores the development of automation and robotics to satisfy the demand to produce in high yield and purity and to screen huge numbers of molecules. This second edition has been revised and updated to include important topics such as catalysis and biotechnology applications and includes a new chapter describing current ICS-UNIDO activities. Zusammenfassung Covers the various methodologies used in the design, synthesis, and screening of molecular libraries. This work explores areas such as catalysis, applications in biotechnology, and ICS-UNIDO activities. It also illustrates the importance of economics and patenting in combinatorial technologies. Inhaltsverzeichnis Automation in Combinatorial Chemistry. Computational Aspects of Combinatorial Chemistry. High Throughput Combinatorial Methods for Heterogeneous Catalysts Design and Development. Biological Libraries. Peptide Display Libraries: Design and Construction. Making and Selecting from Phage Antibody Libraries. Biopanning. Oligonucleotide Library Preparation and Screening. Application of Selex Technology to Drug and Diagnostic Development. Combinatorial Proteomic. A Combinatorial Approach to Gene Expression Analysis: DNA Microarrays. Economics of Combinatorial Chemistry and Combinatorial Technologies. ...
