Handbook of Neurotoxicology - Volume 2

Neurotoxins-whether natural products that can provide valuable therapeutic agents and research reagents or human-generated pollutants-have recently attracted great scientific interest. In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. This second volume of the Handbook focuses on the biologic effects of human-made toxins on the developing organism, and of drugs of abuse. Here are discussed the interpretation of neurotoxicity data, the art of risk assessment, and the manifestation of CNS insult during development. The drugs of abuse surveyed include cocaine, marijuana, the cannabinoids, and amphetamines. Also provided are state-of-the-art methods for the evaluation of neurotoxicant effects by both imaging and neurobehavioral assessment. Volume I concentrates on the biological effects of both human-made neurotoxins (pesticides, mercury, lead, zinc, and polytypic by-products of combustion and manufacture) and those of natural origin (microbial and animal toxins).

Up-to-date and timely, the Handbook of Neurotoxicology, Volumes I and II, not only affords today's biomedical and clinical investigators a full panoply of knowledge in all the critical areas of current neurotoxicologic interest, but also illuminates the latest methodologies for assessing the effects of a broad spectrum of significant neurotoxicological agents.

List of contents

"Part I. Developmental Neurotoxicology
James L. Schardein, Section Editor

Developmental Neurotoxicity: Testing and Interpretation
Judith W. Henck

Manifestations of CNS Insult During Development
Susan A. Rice

Developmental Neurotoxicology: What Have We Learned from Guideline Studies?
Gregg D. Cappon and Donald G. Stump

Risk Assessment of Developmental Neurotoxicants
Hugh A. Tilson

Part II. Drugs of Abuse
Patricia A. Broderick, Section Editor

Electrophysiologic Evidence of Neural Injury or Adaptation in Cocaine Dependence
Kenneth R. Alper, Leslie S. Prichep, E. Roy John, Sharon C. Kowalik, and Mitchell S. Rosenthal

Addictive Basis of Marijuana and Cannabinoids
Eliot L. Gardner

Dopamine and Its Modulation of Drug-Induced Neuronal Damage
Donald M. Kuhn

NMDA Antagonist-Induced Neurotoxicity and Psychosis: The Dissociative Stimulation Hypothesis
Kevin Noguchi

Emerging Drugs of Abuse: Use Patterns and Clinical Toxicity
Katherine R. Bonson and Matthew Baggott

Mechanisms of Methamphetamine-Induced Neurotoxicity
Jean Lud Cadet and Christie Brannock

Neurotoxic Effects of Substituted Amphetamines in Rats and Mice: Challenges to the Current Dogma
James P. O'Callaghan and Diane B. Miller

Studies of Neural Degeneration Indicate that Fasciculus Retroflexus Is a Weak Link in Brain for Many Drugs of Abuse
Gaylord Ellison

Microsensors Detect Neuroadaptation by Cocaine: Serotonin Released in Motor Basal Ganglia Is Not Rhythmic with Movement
Patricia A. Broderick

Part III. Imaging
Thomas E. Schlaepfer, Section Editor

Impact of Intoxication: Structural and Functional Modifications in the Brain Induced by Ethanol Response
David J. Lyons, Cory S. Freedland, and Linda J. Porrino

Structural and Functional Neuroimaging of the "

Summary

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Additional text

"This book presents a set of 21 well-chosen, up to date, reviews of a range of important topics of direct interest to neurotoxicologists in particular, but also to anyone with an interest in animal models of nervous system disease or in pathogenesis. As the title of this proposed series of volumes implies, the editors intend to cover the whole of the field, by adding further volumes in response to reader's requests - so no excuses for gaps!...The coverage is wide...It would be a pity if the emphasis on drugs of abuse put non-specialists off buying the book, because the strong mechanistic treatment of many of the chapters emphasizes the useful parallels with other, less "stimulating", neurotoxic agents. This is certainly not a book just about overdose pharmacology. " - Newsletter of the British Toxicological Society

"The Handbook of Neurotoxicology is an essential addition to the library of any serious researcher in any field of neurotoxicology and should be available in all university libraries where chemistry, biochemistry, or medical or life sciences are studied." - Journal of Natural Products

"Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology." Le Journal Canadien Des Sciences Neurologies

Product details

• Assisted by: Edwar J Massaro (Editor), Edward J Massaro (Editor), Edward J. Massaro (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2002
• EAN: 9780896037960
• ISBN: 978-0-89603-796-0
• No. of pages: 594
• Weight: 1490 g
• Illustrations: Illustr.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; B, neuroimaging, Lead, marijuana, Pharmacology, ZINC, psychosis, Biomedical and Life Sciences, Pharmacology/Toxicology, pesticide, neurobehavioral assessment, neurotoxicology, drugs of abuse, developmental neurotoxicology, neural degeneration