G Protein-Coupled Receptors - Structure, Function, and Ligand Screening

Informationen zum Autor Tatsuya Haga! Shigeki Takeda Klappentext This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels! this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation. Zusammenfassung A guide to G-protein-coupled receptors. It is suitable for those who are developing therapeutic approaches to diseases using drugs that influence receptor activation. Inhaltsverzeichnis Screening of Ligands for GPCRs. Screening of Endogenous Ligands for Orphan GPCRs. Screening of Ligands for Human GPCRs by the Use of Receptor-Ga Fusion Proteins. Screening and Identification of Ghrelin, an Endogenous Ligand for the Growth-Hormone-Secretagogue Receptor. Ligand Screening of Olfactory Receptors. Functions and Regulation of GPCRs. Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice. Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors. Analysis of the Regulation of Muscarinic Acetylcholine Receptors. Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells. Oligomerization of G Protein-Coupled Purinergic Receptors. Tertiary Structure of GPCRs and their Ligands. Methods and Results in X-ray Crystallography of Bovine Rhodopsin. Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect). Modeling of G Protein-Coupled Receptors for Drug Design.

Product details

• Authors: Haga Haga, Tatsuya Haga, Tatsuya (Gakushuin University Haga, Tatsuya Takeda Haga, Shigeki Takeda, Takeda Shigeki
• Assisted by: Tatsuya Haga (Editor), Tatsuya (Gakushuin University Haga (Editor), Haga Tatsuya (Editor), Shigeki Takeda (Editor), Shigeki (Gunma University Takeda (Editor), Takeda Shigeki (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 04.08.2005
• EAN: 9780849327711
• ISBN: 978-0-8493-2771-1
• No. of pages: 336
• Series: Methods in Signal Transduction Series; Methods in Signal Transduction Series
• Subjects: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics; SCIENCE / Life Sciences / Biochemistry, biochemistry, proteins