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Informationen zum Autor Jeff Bakal PhD, P.Stat. is the Program Director for Provincial Research Data Services at Alberta Health Services which operates the Alberta Strategy for Patient Oriented Research (SPOR) data platform and Health Service Statistical & Analytics Methods teams. He has over 10 years of experience working with Health Services data and Randomized Clinical Trials. He completed his PhD jointly with the Department of Mathematics and Statistics and the School of Physical Health and Education at Queen's University. He has worked on the methodology and analysis of several international studies in business strategy, ophthalmology, cardiology, geriatric medicine and the analysis of kinematic data resulting in several peer reviewed articles and conference presentations. His current interests are in developing statistical methodology for time-to-event data and the development of classification tools to assist in patient decision making processes. Daniel Kim works in Radiation Oncology at the Inova Schar Cancer Institute, Fairfax, VA, USA. David E. Wazer, MD, is Professor and Chairman of the Department of Radiation Oncology at Brown University. He is radiation oncologist-in-chief at Rhode Island Hospital, the Miriam Hospital, Newport Hospital, and Women and Infants Hospital. He serves as Director of the Lifespan Cancer Institute. Dr. Wazer’s current areas of clinical research include the study of the efficacy, toxicity, and cost/utility analysis of image-guided radiation therapy, proton beam radiotherapy, partial breast irradiation, and brachytherapy. He is actively involved in the development of clinical trials for cancers of the breast, skin, GI tract, and lung. He is also actively engaged in multiple initiatives to promote and advance oncology care in the developing world. Adam E. M. Eltorai , MD, PhD completed his graduate studies in Biomedical Engineering and Biotechnology along with his medical degree from Brown University. His work has spanned the translational spectrum with a focus on medical technology innovation and development. Dr. Eltorai has published numerous articles and books. Klappentext Translational Radiation Oncology covers the principles of evidence-based medicine and applies them to the design of translational research. The book provides valuable discussions on the critical appraisal of published studies and recent developments in radiation oncology, allowing readers to learn how to evaluate the quality of such studies with respect to measuring outcomes and make effective use of all types of evidence. By reading this book, researchers have access to a practical approach to help them navigate challenging considerations in study design and implementation. It is a valuable resource for researchers, oncologists and members of biomedical field who want to understand more about translational research applied to the field of radiation oncology. Translational medicine serves as an indispensable tool in grant writing and funding efforts, so understanding how to apply its principles to research is necessary to guarantee that results will be impactful to patients. Inhaltsverzeichnis INTRODUCTION 1. Introduction; 2. Translational Process; 3. Scientific Method; 4. Basic Research PRE-CLINCIAL: DISCOVERY AND DEVELOPMENT 5. Overview of Preclinical Research; 6. What problem are you Solving?; 7. Types of Interventions; 8. Drug discovery; 9. Drug Testing; 10. Device Discovery and Prototyping; 11. Device Testing; 12. Diagnostic Discovery; 13. Diagnostic Testing; 14. Procedural Technique Development; 15. Behavioral Intervention; 16. Artificial Intelligence CLINICAL: FUNDAMENTALS 17. Introduction to clinical research: What is it? Why is it needed?; 18. The question: Types of research questions and how to develop them; 19. Study population: Who and why them?; 20. Outcome measurements: What data is being collected and why?; 21. Optimi...
