Antimalarial Natural Products

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.

List of contents

Chapter 1. Antimalarial Natural Products.

Product details

• Assisted by: Yoshinori Asakawa (Editor), Verena M. Dirsch (Editor), Heinz Falk (Editor), Simon Gibbons (Editor), Simon Gibbons et al (Editor), A. Douglas Kinghorn (Editor), Ji-Kai Liu (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 05.01.2023
• EAN: 9783030898755
• ISBN: 978-3-0-3089875-5
• No. of pages: 106
• Dimensions: 155 mm x 6 mm x 235 mm
• Illustrations: IX, 106 p. 112 illus., 8 illus. in color.
• Series: Progress in the Chemistry of Organic Natural Products
• Subject: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics