Synthetic Nucleic Acids As Inhibitors of Gene Expression - Mechanisms, Applications, and Therapeutic Implications

Informationen zum Autor Levon Michael Khachigian Zusammenfassung Presents the research on inhibitors of gene expression and nucleic acid-based drugs. This book features numerous charts, diagrams, and graphs. It covers the subject from lab bench to cancer-related clinical trials. It describes mechanisms and multiple therapeutic applications of double-stranded oligonucleotide decoys. Inhaltsverzeichnis Therapeutic Application of Ribozymes for Cardiovascular Disease! Noboru FukudaDevelopment of Ribozymes as Cancer Therapeutics! Mehdi Nosrati! Kevin Scanlon! and Mohammed Kashani-SabetRNA Interference: A Technology Based on an Ancient Gene Silencing Pathway! Mike McManus and Brian D. HarfeRNA-Cleaving DNA Enzymes in Gene Silencing: Room for Improvement? Stephen W. SantoroDeoxyribozymes and Medical Innovation! Gail Mitchell Emilsson and Ronald R. BreakerEffect of Modifications on the Intracellular Activity of a DNA Enzyme! Masaki Warashina! Barbara Nawrot! Satoshi Obika! Lucyna A. Woniak! Tomoko Kuwabara! Takeshi Imanishi! Wojciech J. Stec! and Kazunari TairaPotential Therapeutic Applications of DNA Enzymes and siRNAs Against Viral and Cellular Genes! Akhil C. Banerjea! Samitabh Chakraborti! Hoshang Unwalla! Ritu Goila!Basu Shrabani! Bipin C. Dash! Bandi Sriram! Natrajan Paramasivam! andSaraswathi ViswanathanUse of DNAzymes for Target Gene Validation! Michael Eisbacher and Lun-Quan SunDNAzymes Targeting Immediate-Early Genes as Inhibitors of Angiogenesis and Restenosis! Levon M. KhachigianDecoy Oligodeoxynucleotides as Viable Pharmaceutical Drugs! Ryuichi Morishita! Naruya Tomita! and Toshio Ogihara

Product details

• Authors: Levon Michael Khachigian, Levon Michael (University of New South Khachigian, Khachigian Levon Michael, Saraswathi Viswanathan
• Assisted by: Levon Michael Khachigian (Editor), Levon Michael (University of New South Wales Khachigian (Editor), Khachigian Levon Michael (Editor)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 29.11.2004
• EAN: 9780849330254
• ISBN: 978-0-8493-3025-4
• No. of pages: 204
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / General, MEDICAL / Biochemistry, SCIENCE / Life Sciences / Molecular Biology, MEDICAL / Biotechnology, biochemistry, molecular biology, biotechnology