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Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.
List of contents
Evaluation of Mitochondrial Function in Intact Cells.- Flow Cytometric Analysis of Mitochondrial Function.- Confocal Microscopy of Mitochondrial Function in Living Cells.- Mitochondrial Disease and Aging.- Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-Related Disorders.- Transmission and Segregation of Mammalian Mitochondrial DNA.- Cardiac Reperfusion Injury: Aging, Lipid Peroxidation, and Mitochondrial Function.- Mitochondrial Ion Homeostasis and Necrotic Cell Death.- Ca2+-Induced Transition in Mitochondria: A Cellular Catastrophe?.- Physiology of the Permeability Transition Pore.- Control of Mitochondrial Metabolism by Calcium-Dependent Hormones.- The Permeability Transition Pore in Myocardial Ischemia and Reperfusion.- Mitochondrial Calcium Dysregulation during Hypoxic Injury to Cardiac Myocytes.- Mitochondrial Implication in Cell Death.- Role of Mitochondria in Apoptosis Induced by Tumor Necrosis Factor-?.- The ATP Switch in Apoptosis.- Mitochondria, Free Radicals, and Disease.- Reactive Oxygen Generation by Mitochondria.- Role of the Permeability Transition in Glutamate-Mediated Neuronal Injury.- Mitochondrial Dysfunction in the Pathogenesis of Acute Neural Cell Death.- Varied Responses of Central Nervous System Mitochondria to Calcium.- Mitochondrial Dysfunction in Oxidative Stress, Excitotoxicity, and Apoptosis.- Mitochondria in Alcoholic Liver Disease.- Mitochondrial Changes after Acute Alcohol Ingestion.- Mitochondrial Dysfunction in Chronic Fatigue Syndrome.- Chemical Toxicity.- Bile Acid Toxicity.- Reye's Syndrome and Related Chemical Toxicity.- Purinergic Receptor-Mediated Cytotoxicity.- Doxorubicin-Induced Mitochondrial Cardiomyopathy.- Drug-Induced Microvesicular Steatosis and Steatohepatitis.
Summary
Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease.
