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We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.
About the author
Dr. Adil Mehraj Khan ist Assist. Prof. in Veterinärpharmakologie und -toxikologie an der SKUAST-K, Indien. Er schloss sein Postgraduiertenstudium an der SKUAST-J ab und promovierte an der GADVASU, Ludhiana. Er hat Forschungsarbeiten in angesehenen Fachzeitschriften veröffentlicht und ist außerdem regelmäßiger Gutachter und Mitglied des Redaktionsausschusses hochwertiger Fachzeitschriften.
