Industrialization of Drug Discovery - From Target Selection Through Lead Optimization

Informationen zum Autor Jeffrey S. Handen, Ph.D. Klappentext The pharmaceutical industry suffers from an innovation deficit! with clinical attrition and safety-related market-withdrawal rates at the same level as twenty years ago. This book scrutinizes this problem in detail! contrasting the promise of technology and industrialization with the apparent inability of industry to fully realize the tools that are available. The text begins by introducing the evolution of modern drug discovery! tracing it from basic concepts to current approaches. The editor devotes the remainder of the discussion to the regulatory environment! industrialization! compound and knowledge management functions! the drug screening process! collaboration! and finally! ethical issues. Zusammenfassung The pharmaceutical industry suffers from an innovation deficit, with clinical attrition and safety-related market-withdrawal. This book scrutinizes this problem in detail, contrasting the promise of technology and industrialization with the apparent inability of industry to fully realize the tools that are available. Inhaltsverzeichnis Drug Discovery in the Modern Age: How We Got Here and Where Do We Go?. The Regulatory Age. Industrialization Not Automation. Compound Management. High Throughput Screening. Parallel Lead Optimization. Knowledge Management. ROI – How to Measure It? How to Get It?. Collaboration in a Virtual and Global Environment. From Genome to Drug: Ethical Issues.

Product details

• Authors: Handen S. Handen, Jeffrey S Handen, Jeffrey S. Handen, Ph.D. Handen
• Assisted by: Jeffrey S. Handen (Editor), Ph.D. Handen (Editor), Ph.D. Jeffrey S. Handen (Editor), Jeffrey S. Handen Ph.D. (Editor), Andrew Carmen (Editor of the series)
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 26.05.2005
• EAN: 9780824723910
• ISBN: 978-0-8247-2391-0
• No. of pages: 328
• Series: Drug Discovery Series; Drug Discovery Series
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Medical research, MEDICAL / Pharmacy, SCIENCE / Chemistry / General, MEDICAL / Pharmacology, chemistry, Biology, life sciences, Pharmacology, Pharmaceutical technology, Pharmaceutical chemistry and technology