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This book provides a state-of-the-art overview of acute lymphoblastic leukemia (ALL). The first section of the book presents the translational science behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines current and new advances in ALL treatment, including new monoclonal antibodies and allogenic and autologous HSCT.
Written by experts in the field, Clinical Management of Acute Lymphoblastic Leukemia: From Bench to Bedside is a valuable resource that will guide patient management, stimulate investigative efforts, and increase understanding of the biologic underpinnings of the disease.
List of contents
TRANSLATIONAL SCIENCE.- Molecular pathways and targets in B cell progenitor acute lymphoblastic leukemia.- Genetic Mechanisms in T-Cell Acute Lymphoblastic Leukemia.- Minimal Residual Disease in Acute Lymphoblastic Leukemia - Techniques and Application.- THERAPEUTICS.- Treatment of Pediatric B and T cell ALL.- Treatment of Adult B and T cell Acute Lymphoblastic Leukemia: An Overview of Current Treatments and Novel Advances.- Acute Lymphoblastic Leukemia in Infants: A distinctive, high risk subtype of childhood ALL.- Treatment of Elderly Patients with Acute Lymphoblastic Leukemia.- Treatment of Childhood Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia.- Treatment of adult Philadelphia chromosome positive ALL.- Treatment of Ph-like ALL.- Prophylaxis and treatment of central nervous system (CNS) ALL.- Late effects of therapy of acute lymphoblastic leukemia.- NEW AND EXISTING MODALITIESOF THERAPY.- Monoclonal Antibody Based Treatment and Other New Agents for B-Lineage ALL.- New Agents for the Treatment of T-Cell ALL.- The development and management of treatment with chimeric-antigen receptor T cell (CAR-T).- Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (ALL).- Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.
About the author
Mark R. Litzow, MD
Chair, ECOG-ACRIN Leukemia Committee
Professor of Medicine
Mayo Clinic
Division of Hematology
Rochester, MN
USA
Elizabeth A. Raetz, MD
KiDS of NYU Foundation Professor of Pediatrics, NYU Grossman School of Medicine
Director, Division of Pediatric Hematology/Oncology
NYU Langone Health
New York, NY
USA
