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This book proposes that fetal growth retardation and low-grade systemic inflammation can be prevented by perinatal supplementation of long-chain polyunsaturated fatty acids (LCPUFAs). Evidence for this hypothesis is presented and discussed in detail, along with possible mechanisms by which these substances produce beneficial actions. Finally, it is suggested that provision of adequate amounts of LCPUFAs during the perinatal period prevents insulin resistance, obesity, type 2 diabetes mellitus, hypertension, CHD, and Alzheimer's disease in the adult. Means of testing the hypothesis are also presented. Thus, the book suggests a simple and novel method of preventing diseases that are increasing in incidence in both the developed and developing worlds.
List of contents
1 Introduction Fetal/Perinatal imprinting on later life.- 2 Perinatal origins of adult disease Obesity.- 3 Perinatal origins of adult disease Insulin resistance and Diabetes mellitus.- 4 Perinatal origins ofadult disease Hypertension.- 5 Perinatal origins of adult disease Coronary heart disease.- 6 Metabolic Syndrome X and low-grade systemic inflammation.- 7 Long-chain polyunsaturated fatty acids in adult diseases: A hypothesis.- 8 Breast-feeding Composition and benefits.- 9 Long-chain polyunsaturated fatty acids Metabolism, physiology and clinical significance.- lO A perinatal strategy to prevent adult diseases: The Role of long-chain polyunsaturated fatty acids Clinical implications and testing the hypothesis.
Summary
Proposes that fetal growth retardation and low-grade systemic inflammation can be prevented by perinatal supplementation of long-chain polyunsaturated fatty acids (LCPUFAs). This book presents and discusses evidence for this hypothesis, along with possible mechanisms by which these substances produce beneficial actions.
