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Informationen zum Autor Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts, that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer. Klappentext From first principles to real-world applications-here is the first comprehensive guide to drug discovery and developmentModern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process.The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods.Featuring contributions from a world-class team of experts, Drug Discovery and Development:*Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil)*Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer*Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomicsDrug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry. Zusammenfassung This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Inhaltsverzeichnis Contributors. Preface. 17 Bioactive Molecules in Medicinal Plants: A Perspective on Their Therapeutic Action ( S. C. Taneja and G. N. Qazi ). 17.1 Introduction. 17.2 Evolutionary Relationships Among Plants and Humans. 17.3 Traditional Wisdom. 17.4 Unique Libraries for Plants. 17.5 Drugs and Bioactive Molecules from Plants. 17.6 Synergism in Herbal Formulations. 17.7 Interactions Between Modern Drugs and Natural Products. 17.8 Bioavailability and Bioeffi cacy Enhancers. 17.9 Combination Therapies in Modern Drugs. 17.10 Role of Developments in Technologies and Analytical Tools. 17.11 Herbal Medicine: The Best Possible Route to Health Care. References. 18 Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools ( Steven V. Ley, Ian R. Baxendale, Deborah A. Longbottom, and Rebecca M. Myers ). 18.1 Introduction. 18.2 Solid-Supported Reagents as Tools in Natural Product Synthesis. 18.3 Multistep Use of Supported Reagents in Natural Product Synthesis. 18.4 Conclusions. References. 19 Insulin Sensitizers: Emerging Therapeutics ( Braj B. Lohray and Vidya B. Lohray ). 19.1 Introduction. 19.2 The...
