Fr. 346.00

Assessing Bioavailablility of Drug Delivery Systems - Mathematical Modeling

English · Hardback

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Zusatztext "?it adds new perspectives on topics?[and] gives an overview of the theoretical and experimental work of its senior author."-European Journal of Pharmaceutics and Biopharmaceutics Informationen zum Autor Jean-Maurice Vergnaud, Iosif-Daniel Rosca Klappentext This book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The mathematical models developed by the author are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion! and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance! incorrect dosage! and incorrect frequency! and to determine the best dosage forms necessary for therapy. Zusammenfassung Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, this book elucidates this phenomena. It introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. Inhaltsverzeichnis DEFINITIONSDrugs (Active Agents) and Their Supply Forms (Dosage Forms)Biopharmaceutics and Its GoalPharmacokineticsPharmacodynamicsLiberation of the DrugMembranesBioavailabilityAbsorption of the Drug in the BloodDistribution of the DrugElimination of the DrugTherapeutic IndexDetermination of the Pharmaceutical ParametersINTRAVENOUS ADMINISTRATIONAdministration of a Single DoseRepeated Intravenous Injections (DIV)Continuous Intravenous Infusion (CIV)Repeated Dosage at Constant Flow RateORAL DOSAGE FORMS WITH IMMEDIATE RELEASESingle DoseEffect of the Pharmacokinetic Parameters' ValuesMultiple Oral DosesArea under the Curve with Oral Dosage FormsComparison Between Oral and I.V. Drug DeliveryKINETICS OF DRUG RELEASE FROM ORAL SUSTAINED DOSAGE FORMSDrug Release Controlled by DiffusionDrug Release Controlled by ErosionComparisons and Other Kinetics of ReleaseBIBLIOGRAPHY ON IN VITRO-IN VIVO CORRELATIONSGeneral Survey on In Vitro-In Vivo Problems In Vitro-In Vivo Correlations for Oral Immediate-Release Dosage FormsIn Vitro-In Vivo Correlations with Oral Sustained-Release Dosage FormsPLASMA DRUG LEVEL WITH ORAL DIFFUSION-CONTROLLED DOSAGE FORMSMethods of CalculationResults Obtained for a Single DoseSustained Release with Repeated DosesPrediction of the Characteristics of the Dosage FormPLASMA DRUG LEVEL WITH EROSION-CONTROLLED DOSAGE FORMSMethod of CalculationPlasma Drug Profile with a Single DosePlasma Drug Profile with Repeated MultidosesPrediction of the Characteristics of the Dosage FormsEFFECT OF PATIENT'S NONCOMPLIANCELimited Reliability of the PatientNoncompliance with Erosion-Controlled Dosage FormsNoncompliance with Diffusion-Controlled Dosage FormsDRUG TRANSFER IN VARIOUS TISSUESDrug Transfer into and through the Lung and Bronchial MucusDrug Transfer into the Blister FluidDrug Transfer into EndocarditisTRANSDERMAL THERAPEUTIC SYSTEMSGeneral Mechanisms of Drug DeliveryOverview of the Skin and Its RoleCalculation of the Drug TransportResults for the Transdermal Delivery of MetropololEffect of the Characteristics of the TTSEffect of the Parameters of the Skin ...

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