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The medical device industry faces critical ongoing challenges in the search for new and better materials for advanced medical applications and to replace old materials that no longer stand the test of time. In Biomaterials Engineering and Devices: Human Applications, Volume 1: Fundamentals and Vascular and Carrier Applications, authoritative international experts comprehensively review many current state-of-the-art uses of polymers, metals, and ceramics in the human body. A
veritable encyclopedia of valuable data and experience, this volume not only fully addresses the major issues of compatibility and functionality, but also provides a technical treatise on the design and evaluation of biomaterials for vascular applications and on biomaterials as carriers for bioactive agents. The discussion includes treatment of emerging materials and of the regulatory and technical forces that shape their development. A second volume, Biomaterials Engineering and Devices: Human Applications, Volume 2 is devoted to biomaterials for dental applications, bony biomaterials for grafting applications, and orthopedic fixtures and cements.
Extensively illustrated and referenced, Biomaterials Engineering and Devices: Human Applications, Volume 1: Fundamentals and Vascular and Carrier Applications integrates for today's bioengineering professionals the basic science, engineering, and practical medical experience needed to meet the ever-growing demand for new and better biomaterials.
List of contents
1 Molecular Mechanism of Biomaterial-Mediated Phagocyte Responses.- 2 Hypersensitivity Associated with Metallic Biomaterials.- 3 Blood-Compatible Bioactive Polymers.- 4 Novel Modification Method of Bioprosthetic Tissue for Improved Calcification Resistance.- 5 Biocompatibility of Silicone Gel Breast Implants.- 6 Endothelialization of Vascular Prostheses.- 7 Collagen-Based Vascular Prostheses.- 8 Surface Modifications of Mechanical Heart Valves: Effects on Thrombogenicity.- 9 The Importance of Radial Forces in Vascular Stent Design.- 10 Blood Leak-Proof Porous Vascular Grafts.- 11 Formation of Neointima in Vascular Prosthesis Sealed with Autologous Adipose Tissue Fragments for Femoropopliteal Bypass.- 12 Clinical Improvement in Patients with Coronary and Peripheral Vascular Diseases Treated by LDL-Adsorption Using the Liposorber LA-15 System.- 13 Development of a New Hybrid Coronary Stent Design with Optimized Biocompatible Properties.- 14 Incorporation of Active Agent into Biodegradable Cement: Encapsulation of Agent as Protection from Chemical Degradation During Cure and Effect on Release Profile.- 15 New Synthetic Degradable Polymers as Carrier Materials for BMP.- 16 Use of Carrier Materials in Delivery of Bone Inductor Substances.- 17 Preclinical and Clinical Evaluation of Osteogenic Protein-1 (BMP-7) in Bony Sites.- 18 Enzyme-Based Artificial Liver Support: A Computerized Expert System for Design,Optimization, and Operation Control.- 19 Bupivacaine Release from Biopolymeric Depots for the Alleviation of Postoperative Pain.- 20 Biomaterial Implants for Treatment of Central Nervous System Diseases.
Summary
This volume deals with critical issues concerning biocompatible materials - polymers, metals and other substances used in or on the human body. The focus of the topics range from biopolymers used in controlled release drug delivery systems to biopolymeric plates used in bone repair.
