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This book combines discursive chapters that present the latest progress in molecular biology, drug discovery, organ-tissue engineering, and related fields, with a number of descriptive chapters on methods, protocols, and case studies. Structured into four parts, this volume walks the reader through the latest in cellular biology, with discussions on novel medicinal plant metabolites, nanotechnology in precision medicine, nucleic acid-based therapeutics and vaccines, genetic engineering, computational aid, bioinformatics, synthetic organs for transplantation, and organ-tissue engineering. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that ensures quality results in the lab.
Authoritative and informative, Gene, Drug, and Tissue Engineering serves as an ideal guide for undergraduate students, postgraduate researchers, and senior researchers working in biomedicine and its underlying technologies, stimulating both computational and experimental development and fostering the exchange of new ideas.
List of contents
Gene Alterations Induced by Glutamine (Q) Encoding CAG Repeats Associated with Neurodegeneration.- Latest Trends in Nucleic Acid-Based Engineering Techniques Applied to Precision Medicine.- Nanotechnology Driven Delivery Systems in Inoculation Therapies.- Chronic Kidney Disease: Challenges in Translational Medicine.- Mass Spectroscopy as an Analytical Tool to Harness the Production of Secondary Plant Metabolites: The Way Forward for Drug Discovery.- Assessing the Challenges of Nanotechnology-Driven Targeted Therapies: Development of Magnetically Directed Vectors for Targeted Cancer Therapies and Beyond.- Advances in Regenerative Medicine and Biomaterials.- A Brief Review of Plant Cell Transfection, Gene Transcript Expression, and Genotypic Integration for Enhancing Compound Production.- A Review of Stem Cell Technology Targeting Hepatocyte Growth as an Alternative to Organ Transplantation.- Novel Nanotechnology-Driven Prototypes for AI-Enriched Implanted Prosthetics Following Organ Failure.- Simplified CRISPR-Mediated DNA Editing in Multicellular Eukaryotes.- Design of SaCas9-HF for In Vivo Gene Therapy.- Stem Cell Technology in Organ Transplantation: A Novel Method for 3D Bioprinting Functional and Stable Liver Grafts Using Human iPS-Derived Cells.- In Vitro Assay for the Assessment of Oxygen Depletion Triggers in Human Cell Lines, Associated with Improving Responses to Cancer Therapy.- The Use of 99mTc-Labeled Stem Cells for Evaluation of Chronic Kidney Disease.- An Automated Strategy to Handle Antigenic Variability in Immunization Protocols, Part I: Nanopore Sequencing of Infectious Agent Variants.- An Automated Strategy to Handle Antigenic Variability in Immunization Protocols, Part II: In Vitro Transcribed mRNA Vector Design for Inoculation Against Infectious Agent Variants.
