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The recent convergence of research in stem cell biology, leukemic cell genetics, and drug discovery has provided remarkable insight into pathogenesis and treatment of leukemia and lymphoma. These insights have led to the new therapeutic approaches involving the manipulation of molecular and/or biochemical pathways in leukemia cells. Nonetheless, effective treatment and cures for these blood-related diseases remains, in many cases elusive. This symposium is designed to integrate recent knowledge regarding the basic cellular and molecular biology of leukemia and lymphoma with new approaches to diagnosis and therapy. To this end, a translation research (laboratory to bedside) approach will be encouraged throughout the meeting, with discussions covering new mechanisms regulating hematopoietic cell development, recent new data from clinical trails of new molecular therapeutics, and newly emerging directions in diagnosis. The symposium will bring together basic, translational, and clinical investigators in a meeting aimed at developing potential collaborative interaction. The intension is to provide new insights into the molecular targets for the treatment of blood-related cancers
List of contents
An Overview of Heme Oxygenase; N.G. Abraham. Section I: Physiology/Pathology of Heme Oxygenase and its Products, Carbon Monoxide and Bilirubin. I. Development of Heme Oxygenase Inhibitors for the Prevention of Severe Jaundice in Infants: Studies from Laboratory Bench to New Nursery; A. Kappas. 2. Carbon Monoxide: A Potential Anti-inflammatory Agent and Mediator of Lung Anti-Oxidant Defenses; S.W. Ryter, et al. 3. Correlation of the Altered Vascular Effects of Carbon Monoxide and the Cardiovascular Complications of Diabetes; Rui Wang, et al. 4. Endogenous Carbon Monoxide Has Protective Roles in Neointimal Development Elicited by Arterial Injury; T. Morita, et al. 5. End Tidal Breath Carbon Monoxide (ETCO) Levels in Pregnant Women; D.S. Seidman, et al. 6. The Role of Heme Oxygenase in Pregnancy; P. Hewett, A. Ahmed. 7. Increased Carbon Monoxide in Exhaled Air in Patients with Inflammatory Respiratory Diseases; M. Yamaya, et al. 8. Carbon Monoxide and Iron, by-Products of Heme Oxygenase, Modulate Vascular Endothelial Growth Factor Synthesis in Vascular Smooth Muscle Cells; J. Dulak, et al. Section II: Physiological Function of Heme Oxygenase and the Central Nervous System. 9. CO and Neonatal Cerebral Circulation; C.W. Leffler, et al. 10. Differential Expression of Heme Oxygenase-1 in Rat Brain by Endotoxin (LPS); G. Scapagnini, et al. 11. Role of Heme Catabolism in Neurodegenerative Diseases; A. Takeda, et al. 12. Heme Oxygenase-1 and Alzheimer Disease; Y. Mawal, et al. 13. Early Molecular Mechanisms for the Induction of Neuronal Membran
Summary
Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.
