Simulation for Designing Clinical Trials - A Pharmacokinetic-Pharmacodynamic Modeling Perspective

Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

List of contents

Introduction to Simulation for Design of Clinical Trials. Models for Simulation. Computation in Simulation. Analyses of the Simulations. Perspectives on Clinical Trial Simulation. Applications. Index.

About the author

Hui C. Kimko, Stephen B. Duffull

Summary

Supplying a framework for employing simulation as an experiment, this book discusses how to clinically trial designs according to their probability for success. It gives techniques to define distributions of virtual subjects' characteristics, and methods to determine the sensitivity of the trial design.

Product details

• Assisted by: Stephen B. Duffull (Editor), Duffull Stephen B. (Editor), Hui Kimko (Editor), Hui C. Kimko (Editor)
• Publisher: Taylor and Francis
• Languages: English
• Product format: Hardback
• Released: 12.12.2002
• EAN: 9780824708627
• ISBN: 978-0-8247-0862-7
• No. of pages: 424
• Weight: 940 g
• Series: Drugs and the Pharmaceutical Sciences
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; SCIENCE / Chemistry / General, MEDICAL / Pharmacology, Biology, life sciences, Pharmacology, Pharmaceutical technology, Clinical Trials, Pharmaceutical chemistry and technology