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Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing.
List of contents
1. Introduction on Challenges for Autoimmune Diseases
2. From horror autotoxicus to autoimmunity
3. Flow cytometry in the diagnosis of autoimmune related lymphoproliferative disorder
4. Autoantigens in atopic dermatitis: the characterization of autoantigens and their diagnostic value
5. Current paradigms and challenges in vitiligo translational research
6. The role of the kynurenine-pathway aryl hydrocarbon receptor axis in autoimmune diseases of the skin
7. COVID-19 in Childhood and Phenotypes of Pediatric Inflammatory Multisystem Syndrome
8. Challenges for epigenetics of periodontitis
9. Neutrophil extracellular traps in autoimmunity, renal diseases, and transplantation
10. Membranous nephropathy and the role of autoantibodies in its diagnosis and evolution
11. Testicular immune tolerance and viral infections
12. Ophthalmologic manifestations and management of systemic autoimmune diseases
13. Challenges for diagnosis and treatment of primary biliary cholangitis
14. Modelling autoimmune cholangiopathies as infectious disease
15. Bullous skin diseases and epitope-spreading
16. Dermatologic autoimmunity associated with immune checkpoints inhibitors
17. Insights and strategies to promote immune tolerance in allogenic hematopoietic stem cell transplantation recipients
18. The potential of cellular transplantation to harness autoimmunity and reverse clinical diabetes
About the author
Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals.
