Targeting Oncogenic Driver Mutations in Lung Cancer

Klappentext The recent advances in the field of molecular diagnostic techniques have led to the identification of targetable alterations prompting a paradigm shift in the management of non-small cell lung cancer (NSCLC) and an era of precision oncology. This Element highlights the most clinically relevant oncogenic drivers other than EGFR, their management and current advancements in treatment. It also examines the different challenges in resistance to targeted therapies and diagnostic dilemmas for each oncogenic driver and the future direction of NSCLC management. Inhaltsverzeichnis 1. Introduction; 2. ALK gene rearrangements; 3. ROSI gene rearrangements; 4. RET gene rearrangements; 5. MET alterations; 6. KRAS point mutations; 7. B-RAF point mutations; 8. NTRK1/2/3 gene fusions; 9. ERBB2 (HER2) mutations; 10. Diagnostic strategies; References.

Product details

• Authors: Fawzi Abu Rous, Fawzi (Henry Ford Health System) Abu Rous, Alain Borczuk, Alain (Weill Cornell Medicine) Borczuk, Shirish Gadgeel, Shirish (Henry Ford Health System) Gadgeel, Gadgeel Shirish, Balazs Halmos, Balazs (Montefiore Medical Center and Albert Einstein College of Medicine) Halmos, Matthew Lee, Matthew (Montefiore Medical Center and Albert Lee, Matthew (Montefiore Medical Center and Albert Einstein College of Medicine) Lee, Matthew Abu Rous Lee, Lee Matthew, Stephen Liu, Stephen (Comprehensive Cancer Center Liu, Stephen (Lombardi Comprehensive Cancer Center Liu
• Publisher: Cambridge University Press ELT
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2023
• EAN: 9781009336130
• ISBN: 978-1-0-0933613-0
• No. of pages: 75
• Series: Elements in Molecular Oncology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Oncology, MEDICAL / Oncology / General