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Informationen zum Autor David Whitford , Queen Mary & Westfield College, London, UK. Klappentext Einen hervorragenden Überblick über Strukturen und Funktionen von Proteinen bietet Ihnen dieser Band, der insbesondere für Studenten unterer Semester konzipiert ist. Der Autor arbeitet die Bedeutung der Proteine und der Proteinfaltung in der Biochemie anschaulich heraus und hilft Ihnen damit, eine solide Grundlage für speziellere Studien zu schaffen. Vom zugehörigen Webserver können animierte Proteinstrukturen und Übungsaufgaben mit Lösungen abgerufen werden; außerdem finden Sie dort Links zu Proteindatenbanken und anderen einschlägigen Webseiten. Zusammenfassung * An accessible introduction to the principles of protein structure and function. * Beautifully illustrated throughout in full colour. * Includes end of chapter problems, references to further reading and a full glossary of terms. * Associated website including web-based tutorials, problems and additional content. . Inhaltsverzeichnis Preface xi 1 An Introduction to protein structure and function 1 A brief and very selective historical perspective 1 The biological diversity of proteins 5 Proteins and the sequencing of the human and other genomes 9 Why study proteins? 9 2 Amino acids: the building blocks of proteins 13 The 20 amino acids found in proteins 13 The acid-base properties of amino acids 14 Stereochemical representations of amino acids 15 Peptide bonds 16 The chemical and physical properties of amino acids 23 Detection, identification and quantification of amino acids and proteins 32 Stereoisomerism 34 Non-standard amino acids 35 Summary 36 Problems 37 3 The three-dimensional structure of proteins 39 Primary structure or sequence 39 Secondary structure 39 Tertiary structure 50 Quaternary structure 62 The globin family and the role of quaternary structure in modulating activity 66 Immunoglobulins 74 Cyclic proteins 81 Summary 81 Problems 83 4 The structure and function of fibrous proteins 85 The amino acid composition and organization of fibrous proteins 85 Keratins 86 Fibroin 92 Collagen 92 Summary 102 Problems 103 5 The structure and function of membrane proteins 105 The molecular organization of membranes 105 Membrane protein topology and function seen through organization of the erythrocyte membrane 110 Bacteriorhodopsin and the discovery of seven transmembrane helices 114 The structure of the bacterial reaction centre 123 Oxygenic photosynthesis 126 Photosystem I 126 Membrane proteins based on transmembrane ß barrels 128 Respiratory complexes 132 Complex III, the ubiquinol-cytochrome c oxidoreductase 132 Complex IV or cytochrome oxidase 138 The structure of ATP synthetase 144 ATPase family 152 Summary 156 Problems 159 6 The diversity of proteins 161 Prebiotic synthesis and the origins of proteins 161 Evolutionary divergence of organisms and its relationship to protein structure and function 163 Protein sequence analysis 165 Protein databases 180 Gene fusion and duplication 181 Secondary structure prediction 181 Genomics and proteomics 183 Summary 187 Problems 187 7 Enzyme kinetics, structure, function, and catalysis 189 Enzyme nomenclature 191 Enzyme co-factors 192 Chemical kinetics 192 The transition state and the action of enzymes 195 The kinetics of enzyme action 197 Catalytic mechanisms 202 Enzyme structure 209 Lysozyme 209 The serine proteases 212 Triose phosphate isomerase 215 ...
