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Informationen zum Autor Kevin J. Yarema Klappentext The structure! function! and composition of many of the complex carbohydrates found in nature have been described by analytical chemistry and the composition of biosynthetic machinery used to build them has been revealed by advances in genome sequencing. This has set the stage for the active manipulation of carbohydrate structure and intervention in the glycosylation process. The Handbook of Carbohydrate Engineering provides an overview of the basic science! theory! methods! and applications of this broad! interdisciplinary field. It offers a cohesive! coordinated approach to carbohydrate engineering that will serve as an invaluable reference for laboratory researchers and students alike. Zusammenfassung Explores research methodologies used in the characterization and synthesis of carbohydrates. This book emphasizes methods to characterize glycosylation pathways and expounds upon the role of carbohydrates in health and disease. It discusses biomedical applications, including the development of vaccines, therapeutics and glycomimetics. Inhaltsverzeichnis Mammalian Glycosylation: An Overview of Carbohydrate Biosynthesis. Patterning of Lectins of Vero and MDCK Cells and Influenza Viruses: The Search for Additional Virus/Cell Interactions. O-Acetyl Sialic Acids in Parasitic Diseases. Congenital Disorders of Glycosylation. Role of Milk Carbohydrates in Preventing Bacterial Adhesion. Structural Characterization of Glycosaminoglycans. Carrageenans: Structural and Conformational Studies. Computational Modeling in Glycosylation. Biosynthetic Pathways for Differential Expression of Functional Chondroitin Sulfate and Heparan Sulfate. Large-Scale Production of Oligosaccharides Using Engineered Bacteria. Fructan Biosynthesis in Genetically-Modified Plants. Chinese Hamster Ovary (CHO) Glycosylation Mutants for Glycan Engineering. Biochemical Engineering of Sialic Acids. Glycosylation in Native and Engineered Insect Cells. N-Glycan Engineering in Yeasts and Fungi: Progress Toward Human-Like Glycosylation. Bacterial Capsules: A Route for Polysaccharide Engineering. Chemo-Biological Approach to Modification of the Bacterial Cell Wall. Engineering Bacterial Biopolymers for the Biosorption of Heavy Metals. Treatment of Wastewaters with the Biopolymer Chitosan. The Role of Glycosylation in Engineered Antibodies. Recent Developments in the Synthesis of Oligosaccharides by Hyperthermophilic Glycosidases. Modification of Plant Cell Wall Polysaccharides Using Enzymes from Aspergillus. ß-Glucosidases from Filamentous Fungi: Properties! Structure! and Applications. Sialic Acids and Sialylmimetics: Useful Chemical Probes of Sialic Acid-Recognizing Proteins. Engineering Carbohydrate Scaffolds into the Side Chains of Amino Acids and Use in Combinatorial Synthesis. Effects of Short- and Long-Chain Fructans on Large Intestinal Physiology and Development of Pre-Neoplastic Lesions in Rats. Alginate as Drug a Delivery Carrier. Chitosan-Based Nonviral Vectors for Gene Delivery. Polysaccharides in Tissue Engineering Applications. Index ...
