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This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
List of contents
Section I: Normal Cardiomyocyte and its Growth.- 1. Structure and Function of Cardiomyocyte.- 2. Development of Cardiomyocyte.- 3. Cell Cycle Regulation in Cardiomyocytes .- 4. Cardiac Fibroblast and Cardiomyocyte Growth.- 5. Role of Endocardium and Epicardium in Generation of Cardiomyocytes.- Cardiomyocytes in the Mammalian Adult Heart.- 7. Energy Metabolism in Cardiomyocytes.- Section II: Cardiomyocyte Responses8. Response of Cardiomyocytes to Mechanical Stress.- Cardiomyocyte Responses to Hormones10. Sequelae of Genetic Defects in Cardiomyocytes.- 11. Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart.- Section III: Cardiomyocyte Aging and Death.- 12. Cardiomyocyte Senescence.- 13. Mechanisms of Cardiomyocyte Death.- 14. Cardiomyocyte Response to Ischemic Injury.- 15. Cardiomyocytes in Heart Failure.- Section IV: Cardiomyocyte Regeneration.- 16. Endogenous Mechanisms for Cardiomyocyte Regeneration.- 17. Mechanisms to Induce Cardiomyocyte Proliferation.- 18. Cell Sources of Cardiomyocytes for Heart Repair.- 19. Reprograming Fibroblasts for Cardiomyocytes and Progenitors.- Section V: Translational Aspects of Cardiomyocyte Biology.- 20. Clinical Translation of Discoveries in Cardiomyocyte Biology.
