Taurine 4 - Taurine and Excitable Tissues

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the "setpoint" andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

List of contents

Keynote Presentation.- Appreciations.- Plenary Presentations.- Basic Aspects and Peripheral Actions of Taurine.- Metabolic and Nutritional Aspects.- Taurine in the CNS.- Taurine Analogues and Metals: Health Care Aspects.- Taurine and Vision.- Taurine and Cell Homeostatic Mechanisms.- Clinical Aspects.

Product details

• Assisted by: Laura Della Corte (Editor), Ryan J Huxtable (Editor), Ryan J. Huxtable (Editor), Ryan J Huxtable (Editor), Giampietro Sgaragli (Editor), Giampietro Sgaragli et al (Editor), Keith F Tipton (Editor), Keith F. Tipton (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2001
• EAN: 9780306464478
• ISBN: 978-0-306-46447-8
• No. of pages: 652
• Weight: 1125 g
• Illustrations: XXIV, 652 p.
• Series: Advances in Experimental Medic; Advances in Experimental Medicine and Biology
• Subject: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics