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This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.
List of contents
Marine Bioactive Heterocyclic Compounds (Manzamine and Xestoquinone).- Total Synthesis of Manzamine Alkaloids.- Recent Progress on the Total Synthesis of Dictyodendrins.- Marine Bioluminescence with Imidazopyrazinones.- Chemical and Biological Aspects of Water Soluble Marine Natural Products.- Saxitoxin, a Shellfish Toxin.- Natural Products Screening from Marine Actinomycetes and Bacteria.- Siderophores from Fish Pathogenic Bacteria.- Marine Natural Products Inhibitors of Leishmaniasis.- Total Synthesis of the Amicoumacin Family of Natural Products.- Bioactive Substances from Marine Cyanobacteria.- Cyclic Depsipeptide, Callipeltins.- Synthesis of Marine Macrodiolide Natural Products.- Total Synthesis of Marine Macrolide Natural Products.- Marine Polyethers.- Biosynthesis of Sponge-derived Bioactive Compounds.- Chlorsulpholipids.- Azaspiracid Synthesis, Structure, and Detection.- Structural Elucidation of Callipeltosides A, B and C.
About the author
Hiromasa Kiyota (b. 1966; Sendai, Japan) is a professor of chemistry at Okayama University, Japan. He obtained his B. S., M. S., and Ph.D. degrees from The University of Tokyo and assumed the position of assistant professor in Prof. K. Mori's laboratory there. After moving to Prof. T. Oritani's laboratory at Tohoku University in 1994, he was promoted to associate professor (in Prof. S. Kuwahara's laboratory) in 2002 and spent time in the research group of Prof. Steven V. Ley at Cambridge University, U.K., as a visiting academic (2001-2002). In 2013 he moved to Okayama University to start a new natural product chemistry research laboratory. He has received several awards, e. g., The Japan Bioscience, Biotechnology and Agrochemistry Society Award for the Encouragement of Young Scientists; and the Society Award for Prominent Achievement of the Pesticide Science Society. He is the author or co-author of 240 publications, 12 patents, and 8 books. His research interests extend throughout a wide range of natural product chemistry, with in-depth expertise on the synthesis of biologically active compounds such as antibiotics, phytotoxins, plant hormones, insect pheromones, marine products, and perfumery.
