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Familiarity with nitric oxide is essential to a modern understanding of pathophysiologic mechanisms of infectious disease. Recent research has established nitric oxide and related reactive nitrogen intermediates to be important molecular mediators of diverse physiologic processes such as control of vascular tone, regulation of the immune system, and microbial and tumor cell growth. This book contains chapters by the leading researchers in the field and examines the biology and biochemistry of nitric oxide and its role in a variety of specific infections ranging from sepsis, tuberculosis and malaria to viral myocarditis, influenza, and AIDS.
List of contents
An Overview of Nitric Oxide in Infection.- Historical Aspects of Nitric Oxide.- The Discovery of the Biological Synthesis of Nitric Oxide.- Biological Roles of Nitric Oxide.- Biochemistry of Nitric Oxide.- Enzymology of Nitric Oxide Biosynthesis.- Cytokine Regulation of Nitric Oxide Production.- Human Mononuclear Phagocyte Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression.- Cardiovascular Actions of Nitric Oxide.- Biochemical Regulation of Nitric Oxide Cytotoxicity.- Cytoprotective Effects of NO against Oxidative Injury.- Immunomodulatory Actions of Nitric Oxide.- Nitric Oxide and Epithelial Host Defense.- Antimicrobial Properties of Nitric Oxide.- Nitric Oxide in Specific Infections.- Nitric Oxide in Sepsis.- Nitric Oxide in Mycobacterium tuberculosis Infection.- Nitric Oxide in Malaria.- Nitric Oxide in Schistosomiasis.- Nitric Oxide in Leishmaniasis.- Nitric Oxide in Viral Myocarditis.- Nitric Oxide in Influenza.- Nitric Oxide in Bacterial Meningitis.- Nitric Oxide in AIDS-Associated Neurological Disease.- Nitric Oxide in Listeriosis.- Future Directions.- Therapeutic Applications of Nitric Oxide in Infection.
Summary
Familiarity with nitric oxide is essential to a modern understanding of pathophysiologic mechanisms of infectious disease. Recent research has established nitric oxide and related reactive nitrogen intermediates to be important molecular mediators of diverse physiologic processes such as control of vascular tone, regulation of the immune system, and microbial and tumor cell growth. This book contains chapters by the leading researchers in the field and examines the biology and biochemistry of nitric oxide and its role in a variety of specific infections ranging from sepsis, tuberculosis and malaria to viral myocarditis, influenza, and AIDS.
