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Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most widely studied disorder of the central nervous system. In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the vitally important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and also reviews microglial cell function and physiology. Cellular neurobiologists will find that this is a valuable guide to the importance and role of microglia in the CNS.
List of contents
1. Physiology and Pathophysiology of Microglial Cell Function.- 2. Roles of Microglia in the Developing Avian Visual System.- 3. Microglial Ion Channels.- 4. Calcium Signaling in Microglial Cells.- 5. Microglia as a Source and Target of Cytokine Activities in the Brain.- 6. Microglia and Macrophage Responses in Cerebral Ischemia.- 7. Role of Microglia and Macrophages in Secondary Injury of the Traumatized Spinal Cord: Troublemakers or Scapegoats?.- 8. Microglial Response in the Axotomized Facial Motor Nucleus.- 9. Neuroprotective Roles of Microglia in the Central Nervous System.- 10. Influences of Activated Microglia/Brain Macrophages on Spinal Cord Injury and Regeneration.- 11. Opportunities for Axon Repair in the CNS: Use of Microglia and Biopolymer Compositions.- 12. Beta Amyloid Protein Clearance and Microglial Activation.- 13. Microglia and Aging in the Brain.
Summary
Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most widely studied disorder of the central nervous system. In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the vitally important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and also reviews microglial cell function and physiology. Cellular neurobiologists will find that this is a valuable guide to the importance and role of microglia in the CNS.
