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Informationen zum Autor Andre Menez is the Director of the Department of Protein Engineering at the Commissariat a l'Energie Atomique (CEA) in France. He heads the Laboratory of Protein Chemistry and is Professor at the National Institute of Sciences and Nuclear Techniques. Klappentext In diesem Tagungsband stellen Ihnen die Hauptvortragenden des '13th World Congress on Animal, Plant and Microbial Toxins' neueste Entwicklungen auf ihren jeweiligen Fachgebieten vor. Das Themenspektrum reflektiert momentane Forschungsschwerpunkte - die meisten Beiträge beschäftigen sich mit neuartigen Toxinen, die im Meer gefunden wurden. Zusammenfassung Following the 13th World Congress on Animal, Plant and Microbial toxins, key lecturers write about the developments occurring in their specialist field. This work includes contributions that offer perspectives on the new toxins found in nature. Inhaltsverzeichnis List of Contributors Preface I TOXINS FROM MICROORGANISMS Bacterial Toxins with Metalloprotease Activity (O. Rossetto and C. Montecucco) The Cholesterol-dependent Cytolysins: Current Perspectives on Membrane Assembly and Insertion (E. Hotze and R.K. Tweten) Toxin-producing Dinoflagellates (M.J. Holmes and R. Lewis) Involvement of Na+ in the Actions of Ciguatoxins and Brevetoxins that Stimulate Neurotransmitter Release and Affect Synaptic Transmission (J. Molgó and E. Benoit) II ANIMAL TOXINS AND NEW METHODOLOGIES Role of Discovery Science in Toxicology: Examples in Venom Proteomics (J.W. Fox, J.D. Shannon, B. Stefansson, A.S. Kamiguti, R.D.G. Theakston, S.M.T. Serrano, A.C.M. Camargo and N. Sherman) Proteomics of Venom Peptides (R. Stocklin and P. Favreau) High-resolution NMR of Venom Toxins in Nanomolar Amounts (M. Delepierre) III ANIMAL TOXINS: FROM FUNDAMENTAL STUDIES TO DRUGS? Cone Snails and Conotoxins Evolving Sophisticated Neuropharmacology (B.M. Olivera, J.S. Imperial and G Bulaj) Toxin Structure and Function: What Does Structural Genomics Have To Offer? (R.S. Norton) The Sites by which Animal Toxins Bind to their Targets Involve Two Components: A Clue for Selectivity, Evolution and Design of Proteins? (A. Ménez, D. Servent and S. Gasparini) Scorpion Genes and Peptides Specific for Potassium Channels: Structure,Function and Evolution (L.D. Possani, E. Merino, M. Corona and B. Becerril) Scorpion Toxins Differentiating among Neuronal Sodium Channel Subtypes: Nature's Guide for Design of Selective Drugs (D. Gordon, N. Gilles, D. Bertrand, J. Molgó, G.M. Nicholson, M.P. Sauviat, E. Benoit, I. Shichor, I. Lotan, M. Gurevitz, R.G. Kallen and S.H. Heinemann) Diversification of Toxic Sites on a Conserved Protein Scaffold - a Scorpion Recipe for Survival (M. Gurevitz, N. Zilberberg, O. Froy, M. Turkov, R. Wilunsky, I. Karbat, J. Anglister, B. Shaanan, M. Pelhate, M.E. Adams, N. Gilles, D. Gordon) Methodological Approaches to the Study of Ion Channels Using Peptide Toxins: Proposed Comprehensive Guidelines (M. De Waard, J.-M. Sabatier and H. Rochat) Toxins as Probes for Structure and Specificity of Synaptic Target Proteins (P. Taylor, B. Molles, S. Malany and H. Osaka) Allosteric and Steric interactions of Polyamines and Polyamine-containing Toxins with Nicotinic Acetylcholine Receptors (T.J. Brier, I.R. Mellor and P.N.R. Usherwood) Anabaseine as a Molecular Model for Design of a7 Nicotinic Receptor Agonist Drugs (W.R. Kem) Understanding the Structure-Function Relationship of Snake Venom Cardiotoxins (T.K.S. Kumar, S. Srisailam, R.R. Vethanayagam and C. Yu) Structure and Function of Disintegrins and C-lectins: Viper Venom Proteins Modulating Cell Adhesion (S. Niewiarowski, C. Marcinkiewicz, I. Wierzbicka-Patynowski, M.A. McLane and J.J. Calvet...
