Handbook of Copper Pharmacology and Toxicology

Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases.

Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today.

List of contents

"Part I. Copper in Mammals

Biochemistry and Molecular Biology of Copper in Mammals
Maria C. Linder

Part II. Copper Proteins

Biochemistry of the Wilson's Disease Protein
Svetlana Lutsenko, Ruslan Tsivkovskii, Matthew J. Cooper, Brian C. MacArthur, and Hans-Peter Bächinger

Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors, Francesca De Rienzo, R. Razif Gabdoulline, Rebecca C. Wade, and M. Cristina Menziani

Molecular Modeling and Dynamics of Copper Proteins
Mattia Falconi and Alessandro Desideri

The Prion Protein and Copper: What Is the Connection?
Lesley R. Brown and David A. Harris

Prion Protein: A Synaptic Cuproprotein
David R. Brown

Cytochrome-c Oxidase
Shinya Yoshikawa

The Fet3 Protein: A Multicopper Ferroxidase Essential to Iron Metabolism in Yeast
Daniel J. Kosman

Interaction of Copper-Binding Proteins from Enteroccus hirae
Paul A. Cobine, Christopher E. Jones, Wasantha A. Wickramasinghe, Marc Solioz, and Charles T. Dameron

Part III. Copper Transport

Copper Uptake in Eukaryotic Cells
Lisbeth Birk Møller and Nina Horn

The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson's Disease
Jimo Borjigin, Xing Sun, and Michael M. Wang

The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein
Michael J. Francis and Anthony P. Monaco

Intracellular Copper Transport and ATP7B, the Wilson's Disease Protein
Kunihiko Terada and Toshihiro Sugiyama

A Multicopper Oxidase-Based Iron-Transport System in Yeast
Jerry Kaplan

Part IV. Molecular Pathogenesis of Diseases of Copper Metabolism

Molecular Basis of Diseases of Copper Homeostasis
Julian F. B. Mercer, David Kramer, and Ja m"

Summary

Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Additional text

"...biochemical and molecular researchers from around the globe have produced 35 chapters documenting the present state of knowledge in selected areas of copper pharmacology and toxicology. the state-of-the-art data provided will no doubt stimulate challenging research with this essential trace element required by organism ranging from bacteria to mammals." - Veterinary and Human Toxicology

"The book has excellent introductory chapters, and summarizes much recent research at the genetic and cellular levels." - Newsletter of the British Toxicological Society

"Dr. Massaro must be congratulated for editing this comprehensive book on copper. There are so many outstanding chapters in this compendium that highlighting any one of them should not detract from the others...this book is a treasure trove of references. The price of the book, though modest for this compendium would be justified for the Preface and the first chapter alone. This book is highly recommended. At the present time it has no equal." -International Journal of Toxicology

Product details

• Assisted by: Edwar J Massaro (Editor), Edward J Massaro (Editor), Edward J. Massaro (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2002
• EAN: 9780896039438
• ISBN: 978-0-89603-943-8
• No. of pages: 608
• Weight: 1498 g
• Illustrations: Illustr.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; B, Research, METABOLISM, Pharmacology, Biomedical and Life Sciences, Pharmacology/Toxicology, Toxicology, Toxicity