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Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.
List of contents
1 - Animal Models of Folate-Related Neural Tube Defects.- 2 - Genetic Variation in Folate Metabolism: Impacton Development.- 3 - Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome.- 4 - Folic Acid, Vitamin B12, and Genomic Stability of Human Cells.- 5 - Molecular Genetics of Folate Metabolism.- 6 - Folate Receptor-?: An Update.- 7 - Folate, Homocysteine, and Neural Tube Defects.- 8 - Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects.- 9 - Developmental Toxicants Potentially Acting via Folate Perturbation.- 10 - Brain Development and Choline, the Other Methyl Donor.- 11 - Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome.- 12 - Regulation of Folate Metabolism by Iron.- 13 - A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype.- 14 - Vascular Disease in Women: Folate and Homocysteine.- 15 - Folate, Homocysteine, and Cardiovascular Disease.
Summary
Reviews the findings on the role of folate in human development, health, and disease. This book addresses areas such as folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, and developmental toxicants potentially acting via folate perturbation.
Additional text
"This multi-author volume reads like a research symposium. Each chapter, written by experts in their field, can be read independently without reference to the others. There is considerable repetition with several chapters providing, for example, overviews of folate metabolism. This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects." - Human Genetics
"Each chapter is very well referenced and up-to-date." -Journal of Paediatrics and Child Health
"This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects. This book old be a valuable reference source in any department of human genetics." -Human Genetics
Report
"This multi-author volume reads like a research symposium. Each chapter, written by experts in their field, can be read independently without reference to the others. There is considerable repetition with several chapters providing, for example, overviews of folate metabolism. This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects." - Human Genetics
"Each chapter is very well referenced and up-to-date." -Journal of Paediatrics and Child Health
"This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects. This book old be a valuable reference source in any department of human genetics." -Human Genetics
