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Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful in understanding the role of mechanobiology in bone health and bone diseases, as well for investigating novel strategies for diagnosis and therapy of bone diseases.
Cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast and chondrocyte. Cone diseases covered are osteoporosis, scoliosis and osteoarthritis. This comprehensive reference is written for researchers, scientists, clinicians and students.
List of contents
1. Introduction
2. Methods and models for the study of bone cell mechanobiology
3. Osteocyte Mechanobiology
4. Bone marrow mesenchymal stem cell (BM-MSC) Mechanobiology
5. Osteoblast Mechanobiology
6. Osteoclast Mechanobiology
7. Crosstalk among bone cells mechanotransduction
8. Bone cell biomechanics and the whole bone mechanic property
9. Chondrocyte mechanobiology
10. Bone cell and chondrocyte mechanobiology in bone diseases
11. New technologies for bone cell study
About the author
Dr. Qian received her bachelor’s degree in public health, a Master’s in pathology, and her PhD in cell biology. Her areas of focus are biomechanics, mechanobiology, bone metabolism diseases, space biology, space biotechnology, and nuclear acid drugs research; and she has published more than 200 publications and invented more than 30 patents. Dr. Qian is the Associate Editor of Frontiers in Physiology, an Editorial Board Member of Endocrine, Metabolic & Immune Disorders - Drug Targets, Guest Editor of Seminars in Cell and Developmental Biology, and Guest Editor of Frontiers in Cell and Developmental Biology. She was awarded “New Century Outstanding Talents of the Ministry of Education”, “The 9th Shaanxi Youth Science and Technology Award”, “The 2nd Xi'an Young Science and Technology Talent Award”, and “Elsevier 2021 Most Cited Chinese Researchers”.
Dr. Hu received her bachelor’s degree in biology, a Master’s in biomedical engineering, and her PhD in man-machine and environmental engineering. She has an interdisciplinary background spanning mechanobiology, aging biology, bone diseases cell and molecular biology and aerospace medicine research. She has published over 60 peer-reviewed publications, including 2 ESI highly cited papers and 1 top 1% Scopus-indexed journal article. Additionally she has edited a book as editor and filed 12 invention patent applications. She is the Member of the Chinese Society of Biomechanics, Member of American Society of Bone and Mineral Research and International Chinese Musculoskeletal Research Society. She is the Associate Editor of Frontiers in Physiology and Editorial Board Member of Scientific Reports and BMC Musculoskeletal Disorders. Moreover, she serves as Guest Editor for Seminars in Cell and Developmental Biology and Frontiers in Cell and Developmental Biology. She was awarded “Outstanding Paper Award for Young Scientists” by the Committee on Space Research.
